PTSDgene database

SNP Report

Basic Info
Name rs173365 dbSNP Ensembl
Location 17:45823708 - 45823708(+)
Variant Seq G
Ancestral Allele A
Ref Seq A
Minor Allele Frequence 0.348043
Annotation intron_variant; NMD_transcript_variant; non_coding_transcript_variant
Variant Effect intron_variant(ENST00000293493, ENST00000583888, ENST00000352855, ENST00000398285, ENST00000619154, ENST00000339069, ENST00000314537, ENST00000580955, ENST00000347197, ENST00000577353, ENST00000634540, ENST00000634876, ENST00000582766); NMD_transcript_variant(ENST00000583888, ENST00000580955, ENST00000347197); non_coding_transcript_variant(ENST00000634876, ENST00000582766)
SIFT Annotation deleterious_-_low_confidence; deleterious; tolerated
SIFT Variant Effect deleterious_-_low_confidence(ENST00000619154); deleterious(ENST00000339069, ENST00000293493, ENST00000398285, ENST00000634540); tolerated(ENST00000314537, ENST00000352855, ENST00000577353)
PolyPhen Annotation unknown; benign; possibly_damaging
PolyPhen Variant Effect unknown(ENST00000619154); benign(ENST00000339069, ENST00000293493, ENST00000352855, ENST00000398285, ENST00000634540, ENST00000577353); possibly_damaging(ENST00000314537)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Enhancers;Bivalent Enhancer;Weak transcription
No. of Marker's Association Results 1 (Positive: 1; Negative: 0; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
White, S.,2013 Post-hurricane PTSD symptoms In EA sunsamples: B=-0.77, t=-1.99, P-value=0.047 In EA sunsamples: B=-0.77, t=-1.99, P-value=0.047 Nominally associated with higher post-hurricane PTSD symptom...... Nominally associated with higher post-hurricane PTSD symptoms More... Significant

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
CRHR1 corticotropin releasing hormone receptor 1 17q21.31 12(6/6/0)
MAPT-AS1 MAPT antisense RNA 1 17q21.31 Mapped by Literature SNP, Mapped by LD-proxy, rSNP target

SNPs in LD with rs173365 (count: 6)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 1)

LD-proxies (count: 5)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
DND1P1 No Adipose Subcutaneous cis GTEx