PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	White, S.,2013 PMID: 4182958
Citation	White, S., et al. (2013). "Association of CRHR1 variants and posttraumatic stress symptoms in hurricane exposed adults." J Anxiety Disord 27(7): 678-683.
Phenotype	Post-hurricane PTSD diagnosis, Post-hurricane PTSD symptoms
Trauma	2004 Florida hurricane
Study Design	Cross-sectional study
Study Type	Candidate gene association study
Sample Size	626 samples
SNP/Marker Size	12 SNPs
Predominant Ethnicity	Caucasian, Black
Population	European American: 564, African American: 23, Hispanic: 23, Other: 11
Gender	Full sample: 224 males and 400 females, European American Subsample: 203 males and 361 females
Age	Full sample: 140< 60 years; 479>= 60 years, EA Subsample: 108< 60 years; 451>= 60 years

Detail Info

Sample Diagnosis	NWS PTSD module
Related Diagnostic Tools	The National Women's Study (NWS) PTSD module, Self-report data collection occurred 6-9 months after the hurricanes via telephone interview. Interviews were conducted using computer-assisted telephone interview (CATI) methodology, which allows for maximum quality control. From the phone interview, we evaluated: 1) demographic characteristics, 2) social support, 3) exposure to hurricane(s), and 4) PTSD symptoms.
Sample Status	A probability sample of adults was randomly selected from telephone households in counties that were declared "disaster zones" following the 2004 Florida hurricanes through a Random Digit Dial (RDD) procedure. Interested individuals completed a structured telephone interview
Controls Exposed	NA
Replication Size	None
Result Summary	The results show that four SNPs (rs12938031, rs4792887, rs17689966, and rs173365) were nominally significantly related to post-hurricane PTSD symptoms. After correction for multiple testing, rs12938031 and rs4792887 remained associated with post-hurricane PTSD symptoms. Additionally, rs4792887 was associated with post-hurricane diagnosis of PTSD. This study is the first to examine CRHR1 in relation to PTSD in adults, and provides evidence for the importance of CRHR1 variation in the etiology of PTSD.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 14)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs171441	Post-hurricane PTSD symptoms	CRHR1	In EA sunsamples: B=0.33, t=0.96, P-value=0.34	Not associated with higher post-hurricane PTSD symptoms. Not associated with higher post-hurricane PTSD symptoms.	Non-significant
rs173365	Post-hurricane PTSD symptoms	CRHR1	In EA sunsamples: B=-0.77, t=-1.99, P-value=0.047	Nominally associated with higher post-hurricane PTSD symptom...... Nominally associated with higher post-hurricane PTSD symptoms More...	Significant
rs12938031	Post-hurricane PTSD symptoms	CRHR1	In EA sunsamples: B=-0.33, t=-0.46, P-value<0.001	Nominally associated with higher post-hurricane PTSD symptom...... Nominally associated with higher post-hurricane PTSD symptoms, after a Bonferroni adjustment for multiple testing was employed, remained significant. More...	Significant
rs16940686	Post-hurricane PTSD symptoms	CRHR1	In EA sunsamples: B=0.04, t=0.81, P-value=0.42	Not associated with higher post-hurricane PTSD symptoms. Not associated with higher post-hurricane PTSD symptoms.	Non-significant
rs242936	Post-hurricane PTSD symptoms	CRHR1	In EA sunsamples: B=-0.05, t=-0.51, P-value=0.61	Not associated with higher post-hurricane PTSD symptoms. Not associated with higher post-hurricane PTSD symptoms.	Non-significant
rs242939	Post-hurricane PTSD symptoms	CRHR1	In EA sunsamples: B=-0.19, t=-0.57, P-value=0.57	Not associated with higher post-hurricane PTSD symptoms. Not associated with higher post-hurricane PTSD symptoms.	Non-significant
rs17689966	Post-hurricane PTSD symptoms	CRHR1	In EA sunsamples: B=0.76, t=1.98, P-value=0.049	Nominally associated with higher post-hurricane PTSD symptom...... Nominally associated with higher post-hurricane PTSD symptoms More...	Significant
rs242924	Post-hurricane PTSD symptoms	CRHR1	In EA sunsamples: B=-0.40, t=-1.62, P-value=0.11	Not associated with higher post-hurricane PTSD symptoms. Not associated with higher post-hurricane PTSD symptoms.	Non-significant
rs110402	Post-hurricane PTSD symptoms	CRHR1	In EA sunsamples: B=0.03, t=0.09, P-value=0.93	Not associated with higher post-hurricane PTSD symptoms. Not associated with higher post-hurricane PTSD symptoms.	Non-significant
rs12938031	Post-hurricane PTSD diagnosis	CRHR1	OR=0.58, P-value>0.05	Results indicated that rs12938031 was associated with PTSD d...... Results indicated that rs12938031 was associated with PTSD diagnosis. More...	Significant
rs4792887	Post-hurricane PTSD diagnosis	CRHR1	OR=0.18, P-value=.007	Rs4792887 was not significantly related to diagnostic status Rs4792887 was not significantly related to diagnostic status	Non-significant
rs4792887	Post-hurricane PTSD symptoms	CRHR1	In EA sunsamples: B=-0.31, t=-3.22, P-value=0.001	Nominally associated with higher post-hurricane PTSD symptom...... Nominally associated with higher post-hurricane PTSD symptoms, after a Bonferroni adjustment for multiple testing was employed, remained significant. More...	Significant
rs2664008	Post-hurricane PTSD symptoms	CRHR1	In EA sunsamples: B=0.06, t=1.13, P-value=0.26	Not associated with higher post-hurricane PTSD symptoms. Not associated with higher post-hurricane PTSD symptoms.	Non-significant
rs7209436	Post-hurricane PTSD symptoms	CRHR1	In EA sunsamples: B=0.05, t=0.22, P-value=0.83	Not associated with higher post-hurricane PTSD symptoms. Not associated with higher post-hurricane PTSD symptoms.	Non-significant