PTSDgene database

SNP Report

Basic Info
Name rs4458044 dbSNP Ensembl
Location 17:45796361 - 45796361(+)
Variant Seq C
Ancestral Allele G
Ref Seq G
Minor Allele Frequence 0.208866
Annotation downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
Variant Effect downstream_gene_variant(ENST00000634876); intron_variant(ENST00000587305, ENST00000339069, ENST00000398285, ENST00000352855, ENST00000293493, ENST00000634540, ENST00000347197, ENST00000577353, ENST00000582766, ENST00000314537, ENST00000619154); NMD_transcript_variant(ENST00000347197); non_coding_transcript_variant(ENST00000587305, ENST00000582766)
SIFT Annotation deleterious; tolerated
SIFT Variant Effect deleterious(ENST00000430334); tolerated(ENST00000430334, ENST00000581448, ENST00000584420, ENST00000589780)
PolyPhen Annotation benign; possibly_damaging
PolyPhen Variant Effect benign(ENST00000430334, ENST00000581448, ENST00000584420, ENST00000589780); possibly_damaging(ENST00000430334, ENST00000584420)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription;Enhancers;Bivalent Enhancer
No. of Marker's Association Results 1 (Positive: 0; Negative: 1; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Amstadter, A. B.,2011 Acute UCLA PTSD-RI score B=-1.53, t=-0.62, Empirical P-value=1.00 B=-1.53, t=-0.62, Empirical P-value=1.00 No significant result. No significant result. Non-significant

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
CRHR1 corticotropin releasing hormone receptor 1 17q21.31 12(6/6/0)
MAPT-AS1 MAPT antisense RNA 1 17q21.31 Mapped by Literature SNP, Mapped by LD-proxy, rSNP target

SNPs in LD with rs4458044 (count: 0)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
DND1P1 No Adipose Subcutaneous cis GTEx