Gene Report

Basic Info

Approved Symbol	TH
Symbol Alias	DYT5b
Approved Name	tyrosine hydroxylase
Name Alias	tyrosine 3-monooxygenase
Location	11p15.5
Position	chr11:2163929-2171877, -1
External Links	HGNC: 11782 Entrez Gene: 7054 Ensembl: ENSG00000180176 UCSC: uc001lvr.3
No. of Association Results	1 (Positive: 0; Negative: 1; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Nelson, E. C.,2014	PTSD	rs10840490 ; rs10840491	Non-significant

Gene functional annotation

Gene related GO terms (count: 84)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0042136	neurotransmitter biosynthetic process	biological process	IEA	5
GO:0005634	nucleus	cellular component	ISS	81
GO:0042416	dopamine biosynthetic process	biological process	IDA[12457228]	2
GO:0007613	memory	biological process	ISS	11
GO:0055114	oxidation-reduction process	biological process	IEA	18
GO:0033076	isoquinoline alkaloid metabolic process	biological process	IEA	1
GO:0035900	response to isolation stress	biological process	IEA	1
GO:0035902	response to immobilization stress	biological process	IEA	3
GO:0005829	cytosol	cellular component	TAS	78
GO:0016597	amino acid binding	molecular function	IEA	3
GO:0021987	cerebral cortex development	biological process	IEA	5
GO:0071316	cellular response to nicotine	biological process	IEA	2
GO:0032496	response to lipopolysaccharide	biological process	IEA	9
GO:0007507	heart development	biological process	ISS	6
GO:0010259	multicellular organism aging	biological process	IEA	1
GO:0005737	cytoplasm	cellular component	IDA[10907721]	109
GO:0035240	dopamine binding	molecular function	IEA	6
GO:0009414	response to water deprivation	biological process	IEA	1
GO:0003007	heart morphogenesis	biological process	NAS[12113410]	1
GO:0010043	response to zinc ion	biological process	IEA	2
GO:0034617	tetrahydrobiopterin binding	molecular function	IEA	2
GO:0006665	sphingolipid metabolic process	biological process	IEA	1
GO:0019899	enzyme binding	molecular function	IPI[19703902]	13
GO:0035690	cellular response to drug	biological process	IEA	6
GO:0007605	sensory perception of sound	biological process	IEA	2
GO:0018963	phthalate metabolic process	biological process	IEA	2
GO:0032355	response to estradiol	biological process	IEA	9
GO:0043434	response to peptide hormone	biological process	IEA	6
GO:0009653	anatomical structure morphogenesis	biological process	TAS[7715703]	2
GO:0007601	visual perception	biological process	ISS	3
GO:0006585	dopamine biosynthetic process from tyrosine	biological process	NAS[10907721]	1
GO:0009635	response to herbicide	biological process	IEA	2
GO:0001666	response to hypoxia	biological process	IDA[17520326]	13
GO:0008199	ferric iron binding	molecular function	IEA	1
GO:0042418	epinephrine biosynthetic process	biological process	IDA[12457228]	1
GO:0071333	cellular response to glucose stimulus	biological process	IEA	4
GO:0052314	phytoalexin metabolic process	biological process	IEA	1
GO:0015842	aminergic neurotransmitter loading into synaptic vesicle	biological process	IEA	1
GO:0051602	response to electrical stimulus	biological process	IEA	1
GO:0001975	response to amphetamine	biological process	IEA	9
GO:0043005	neuron projection	cellular component	IDA[17135716]	17
GO:0019825	oxygen binding	molecular function	IEA	1
GO:0008016	regulation of heart contraction	biological process	ISS	2
GO:0042214	terpene metabolic process	biological process	IEA	1
GO:0044281	small molecule metabolic process	biological process	TAS	38
GO:0042421	norepinephrine biosynthetic process	biological process	IDA[12457228]	2
GO:0016137	glycoside metabolic process	biological process	IEA	1
GO:0043204	perikaryon	cellular component	ISS	6
GO:0004511	tyrosine 3-monooxygenase activity	molecular function	IDA[2896667\|11943812\|12631248\|16338639\|19703902]; TAS	1
GO:0009898	cytoplasmic side of plasma membrane	cellular component	IDA[12457228]	4
GO:0042423	catecholamine biosynthetic process	biological process	TAS	3
GO:0001963	synaptic transmission, dopaminergic	biological process	ISS	5
GO:0009416	response to light stimulus	biological process	IEA	2
GO:0014823	response to activity	biological process	IEA	5
GO:0071363	cellular response to growth factor stimulus	biological process	IEA	3
GO:0005515	protein binding	molecular function	IPI[11943812\|19703902]	169
GO:0019904	protein domain specific binding	molecular function	IEA	4
GO:0007626	locomotory behavior	biological process	ISS	9
GO:0009651	response to salt stress	biological process	IEA	3
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS	11
GO:0048596	embryonic camera-type eye morphogenesis	biological process	ISS	1
GO:0043473	pigmentation	biological process	TAS[12631248]	2
GO:0005790	smooth endoplasmic reticulum	cellular component	IDA[12457228]	1
GO:0033162	melanosome membrane	cellular component	IDA[12631248]	2
GO:0035176	social behavior	biological process	IEA	9
GO:0046684	response to pyrethroid	biological process	IEA	1
GO:0007612	learning	biological process	ISS	5
GO:0009887	organ morphogenesis	biological process	ISS	2
GO:0008198	ferrous iron binding	molecular function	IEA	1
GO:0043195	terminal bouton	cellular component	IEA	7
GO:0030425	dendrite	cellular component	IEA	19
GO:0045472	response to ether	biological process	IEA	1
GO:0031410	cytoplasmic vesicle	cellular component	IDA[12457228]	4
GO:0031667	response to nutrient levels	biological process	IEA	3
GO:0005739	mitochondrion	cellular component	IEA	29
GO:0051412	response to corticosterone	biological process	IEA	3
GO:0045471	response to ethanol	biological process	IDA[18343820]	18
GO:0006631	fatty acid metabolic process	biological process	IEA	1
GO:0042462	eye photoreceptor cell development	biological process	ISS	3
GO:0071287	cellular response to manganese ion	biological process	IEA	2
GO:0008021	synaptic vesicle	cellular component	IEA	6
GO:0007617	mating behavior	biological process	IEA	1
GO:0042745	circadian sleep/wake cycle	biological process	IEA	1
GO:0042755	eating behavior	biological process	IEA	4

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in PTSDgene
hsa05020	Parkinson's disease	1
hsa00350	Tyrosine metabolism	5

Gene related interactors from protein-protein interactions data in PINA v2 (count: 14)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
TH	YWHAQ	No	--	--	23444366
TH	MAPKAPK2	No	--	--	6150037
TH	TYSND1	No	--	--	22002062
TH	CDK11B	No	--	--	14675149
TH	YWHAB	No	--	--	14675149
TH	PRKACA	No	--	--	2874140
TH	OR2M5	No	--	--	17200106
TH	CAMK2G	No	--	--	6150037
TH	CSNK2A1	No	--	--	14675149
TH	YWHAZ	No	--	association	11359875 , 19801645 , 19801645 , 18181650 , 18181650 , 18181650 , 19801645
TH	MAPK3	No	--	--	1347949 , 1347949
TH	SNCA	No	--	--	11943812
TH	MAPK1	No	--	--	14570886 , 1347949
TH	YWHAG	No	--	association	19801645 , 19801645 , 19801645