Gene Report

Basic Info

Approved Symbol	GRIN2A
Previous Symbol	NMDAR2A
Symbol Alias	GluN2A
Approved Name	glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Location	16p13.2
Position	chr16:9753404-10182754, -1
External Links	HGNC: 4585 Entrez Gene: 2903 Ensembl: ENSG00000183454 UCSC: uc002czo.4
No. of Association Results	1 (Positive: 0; Negative: 1; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Nelson, E. C.,2014	PTSD	rs3859123 ; rs7200719 ; rs9933111	Non-significant

Gene functional annotation

Gene related GO terms (count: 52)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0000186	activation of MAPKK activity	biological process	TAS	7
GO:0030054	cell junction	cellular component	IEA	24
GO:0060079	excitatory postsynaptic potential	biological process	IEA	5
GO:0004972	NMDA glutamate receptor activity	molecular function	IEA	4
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0005783	endoplasmic reticulum	cellular component	IEA	20
GO:0005887	integral component of plasma membrane	cellular component	TAS[8768735]	36
GO:0005262	calcium channel activity	molecular function	IEA	3
GO:0007611	learning or memory	biological process	TAS[7816096]	6
GO:0006810	transport	biological process	TAS[8768735]	8
GO:0007265	Ras protein signal transduction	biological process	TAS	8
GO:0042734	presynaptic membrane	cellular component	IEA	4
GO:0007268	synaptic transmission	biological process	TAS	32
GO:0042177	negative regulation of protein catabolic process	biological process	IEA	1
GO:0043065	positive regulation of apoptotic process	biological process	IEA	12
GO:0038095	Fc-epsilon receptor signaling pathway	biological process	TAS	8
GO:0097481	neuronal postsynaptic density	cellular component	IEA	4
GO:0017146	NMDA selective glutamate receptor complex	cellular component	IDA[10480938]	5
GO:0070588	calcium ion transmembrane transport	biological process	IEA	5
GO:0008270	zinc ion binding	molecular function	ISS	26
GO:0019233	sensory perception of pain	biological process	IEA	9
GO:0007215	glutamate receptor signaling pathway	biological process	TAS[8768735]	2
GO:0007264	small GTPase mediated signal transduction	biological process	TAS	14
GO:0001975	response to amphetamine	biological process	IEA	9
GO:0033058	directional locomotion	biological process	IEA	1
GO:0005515	protein binding	molecular function	IPI[11937501\|17997397]	169
GO:0035235	ionotropic glutamate receptor signaling pathway	biological process	IEA; TAS[8768735]	5
GO:0045471	response to ethanol	biological process	IDA[18445116]	18
GO:0007411	axon guidance	biological process	TAS	16
GO:0045087	innate immune response	biological process	TAS	15
GO:0009611	response to wounding	biological process	IEA	1
GO:0051930	regulation of sensory perception of pain	biological process	IEA	5
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS	11
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	TAS	9
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	11
GO:0008542	visual learning	biological process	IEA	6
GO:0042417	dopamine metabolic process	biological process	IEA	4
GO:0008286	insulin receptor signaling pathway	biological process	TAS	8
GO:0007613	memory	biological process	IEA	11
GO:0009986	cell surface	cellular component	ISS	21
GO:0042493	response to drug	biological process	IEA	25
GO:0048010	vascular endothelial growth factor receptor signaling pathway	biological process	TAS	9
GO:0042428	serotonin metabolic process	biological process	IEA	3
GO:0043005	neuron projection	cellular component	IEA	17
GO:0008021	synaptic vesicle	cellular component	IEA	6
GO:0060291	long-term synaptic potentiation	biological process	IEA	5
GO:0000165	MAPK cascade	biological process	TAS	10
GO:0008104	protein localization	biological process	IEA	4
GO:0045211	postsynaptic membrane	cellular component	IEA	21
GO:0030431	sleep	biological process	IEA	3
GO:0005234	extracellular-glutamate-gated ion channel activity	molecular function	IEA	4
GO:0001964	startle response	biological process	IEA	3

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in PTSDgene
hsa04720	Long-term potentiation	6
hsa04020	Calcium signaling pathway	11
hsa04080	Neuroactive ligand-receptor interaction	22

Gene related interactors from protein-protein interactions data in PINA v2 (count: 6)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
GRIN2A	SPTAN1	No	biochemical	association	9670010 , 9670010
GRIN2A	DLG1	No	--	--	8601796 , 12933808 , 12933808
GRIN2A	PTK2B	Yes	--	--	11478920 , 12576483
GRIN2A	IL16	No	--	--	10479680 , 10479680
GRIN2A	DLG2	No	--	--	9278515
GRIN2A	DLG3	No	--	--	11937501 , 11937501 , 9278515