Gene Report

Basic Info

Approved Symbol	DRD3
Approved Name	dopamine receptor D3
Location	3q13.3
Position	chr3:114128652-114199407, -1
External Links	HGNC: 3024 Entrez Gene: 1814 Ensembl: ENSG00000151577 UCSC: uc010hqn.1
No. of Association Results	2 (Positive: 1; Negative: 1; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 2)

Reference	Phenotype	Marker	Gene's Category
Nelson, E. C.,2014	PTSD	rs6787134	Non-significant
Wolf, E. J.,2014	PTSD diagnosis	rs201252087 ; rs2134655 ; rs2251177 ; rs4646996 ; rs963468 ; rs9817063 ; rs9868039	Significant

Gene functional annotation

Gene related GO terms (count: 59)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA	25
GO:0035483	gastric emptying	biological process	IEA	1
GO:0019904	protein domain specific binding	molecular function	IEA	4
GO:0035240	dopamine binding	molecular function	IBA	6
GO:0035176	social behavior	biological process	NAS[12860355]	9
GO:0050482	arachidonic acid secretion	biological process	IDA[8301582]	3
GO:0042417	dopamine metabolic process	biological process	IC[8301582]	4
GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	molecular function	IBA	2
GO:0002016	regulation of blood volume by renin-angiotensin	biological process	IEA	1
GO:0051898	negative regulation of protein kinase B signaling	biological process	ISS	2
GO:0007611	learning or memory	biological process	NAS[14681904]	6
GO:0032922	circadian regulation of gene expression	biological process	ISS	4
GO:0006874	cellular calcium ion homeostasis	biological process	IDA[7911712]	9
GO:0007612	learning	biological process	NAS[15998189]	5
GO:0045471	response to ethanol	biological process	ISS	18
GO:0045187	regulation of circadian sleep/wake cycle, sleep	biological process	IEA	1
GO:0040014	regulation of multicellular organism growth	biological process	IEA	1
GO:0042493	response to drug	biological process	ISS	25
GO:0035815	positive regulation of renal sodium excretion	biological process	IEA	2
GO:0007626	locomotory behavior	biological process	ISS	9
GO:0030814	regulation of cAMP metabolic process	biological process	IDA[8666994]	2
GO:0005887	integral component of plasma membrane	cellular component	IC[8301582]; IDA[8413587]	36
GO:0002031	G-protein coupled receptor internalization	biological process	IDA[18424554]	3
GO:0007194	negative regulation of adenylate cyclase activity	biological process	IDA[7907363]	5
GO:0051584	regulation of dopamine uptake involved in synaptic transmission	biological process	IC[8301582]	2
GO:0032467	positive regulation of cytokinesis	biological process	IMP[22888021]	2
GO:0048715	negative regulation of oligodendrocyte differentiation	biological process	ISS	1
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IEA	16
GO:0031748	D1 dopamine receptor binding	molecular function	IEA	1
GO:0001975	response to amphetamine	biological process	IEA	9
GO:0001963	synaptic transmission, dopaminergic	biological process	IBA	5
GO:0090325	regulation of locomotion involved in locomotory behavior	biological process	IEA	2
GO:0034776	response to histamine	biological process	IDA[16839358]	3
GO:0005515	protein binding	molecular function	IPI[10692483\|16386234\|18424554\|26460884]	169
GO:0060160	negative regulation of dopamine receptor signaling pathway	biological process	IEA	2
GO:0008284	positive regulation of cell proliferation	biological process	IEA	14
GO:0019216	regulation of lipid metabolic process	biological process	IEA	1
GO:0045776	negative regulation of blood pressure	biological process	ISS	5
GO:0005886	plasma membrane	cellular component	IDA[16386234\|18424554\|20531939]; TAS	99
GO:0014059	regulation of dopamine secretion	biological process	ISS	6
GO:0042995	cell projection	cellular component	IEA	2
GO:0045840	positive regulation of mitotic nuclear division	biological process	ISS	3
GO:0046717	acid secretion	biological process	ISS	1
GO:0050883	musculoskeletal movement, spinal reflex action	biological process	ISS	1
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	biological process	IDA[7907363\|18424554]	3
GO:0048148	behavioral response to cocaine	biological process	IEP[8815892]; ISS	5
GO:0050709	negative regulation of protein secretion	biological process	IDA[16839358]	4
GO:0042220	response to cocaine	biological process	IEP[10415668]	7
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	molecular function	IDA[8301582]; ISS	3
GO:0008542	visual learning	biological process	ISS	6
GO:0045177	apical part of cell	cellular component	IEA	3
GO:0032416	negative regulation of sodium:proton antiporter activity	biological process	IEA	1
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IDA[7911712]	14
GO:0043278	response to morphine	biological process	ISS	6
GO:0060134	prepulse inhibition	biological process	IMP[18325483]	4
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	biological process	IDA[18424554]	1
GO:0030139	endocytic vesicle	cellular component	IEA	4
GO:0008144	drug binding	molecular function	IDA[8413587]; ISS	13
GO:0060161	positive regulation of dopamine receptor signaling pathway	biological process	ISS	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa04080	Neuroactive ligand-receptor interaction	22

Gene related interactors from protein-protein interactions data in PINA v2 (count: 5)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
DRD3	GRB2	No	--	--	11384839 , 11384839
DRD3	EPB41L1	No	--	--	12181426 , 12181426 , 12181426 , 12181426
DRD3	CLIC6	No	--	--	14499480 , 14499480 , 14499480
DRD3	NCS1	No	--	--	12351722 , 12351722
DRD3	GNAI1	No	--	--	10978845