Gene Report

Basic Info

Approved Symbol	GRIN2B
Previous Symbol	NMDAR2B
Symbol Alias	GluN2B
Approved Name	glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Location	12p13.1
Position	chr12:13437942-13981957, -1
External Links	HGNC: 4586 Entrez Gene: 2904 Ensembl: ENSG00000273079 UCSC: uc001rbt.2
No. of Association Results	1 (Positive: 0; Negative: 1; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Nelson, E. C.,2014	PTSD	rs10845847	Non-significant

Gene functional annotation

Gene related GO terms (count: 47)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0007264	small GTPase mediated signal transduction	biological process	TAS	14
GO:0006810	transport	biological process	TAS[8768735]	8
GO:0005234	extracellular-glutamate-gated ion channel activity	molecular function	IEA	4
GO:0035235	ionotropic glutamate receptor signaling pathway	biological process	IEA; TAS[8768735]	5
GO:0045471	response to ethanol	biological process	IDA[18445116]	18
GO:0008286	insulin receptor signaling pathway	biological process	TAS	8
GO:0010738	regulation of protein kinase A signaling	biological process	IEA	1
GO:0070588	calcium ion transmembrane transport	biological process	IEA	5
GO:0038095	Fc-epsilon receptor signaling pathway	biological process	TAS	8
GO:0016594	glycine binding	molecular function	IDA[17047094]	2
GO:0043005	neuron projection	cellular component	ISS	17
GO:0007411	axon guidance	biological process	TAS	16
GO:0005262	calcium channel activity	molecular function	IEA	3
GO:0048266	behavioral response to pain	biological process	IEA	1
GO:0048013	ephrin receptor signaling pathway	biological process	TAS	3
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS	11
GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	biological process	IEA	3
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0008021	synaptic vesicle	cellular component	IEA	6
GO:0001662	behavioral fear response	biological process	IEA	7
GO:0001967	suckling behavior	biological process	IEA	3
GO:0007613	memory	biological process	IEA	11
GO:0045211	postsynaptic membrane	cellular component	IEA	21
GO:0007612	learning	biological process	IEA	5
GO:0007268	synaptic transmission	biological process	TAS	32
GO:0001964	startle response	biological process	IEA	3
GO:0007215	glutamate receptor signaling pathway	biological process	TAS[8768735]	2
GO:0005515	protein binding	molecular function	IPI[11937501\|17047094\|17997397\|19453375]	169
GO:0030054	cell junction	cellular component	IEA	24
GO:0001701	in utero embryonic development	biological process	IEA	3
GO:0000165	MAPK cascade	biological process	TAS	10
GO:0005887	integral component of plasma membrane	cellular component	TAS[8768735]	36
GO:0045087	innate immune response	biological process	TAS	15
GO:0017146	NMDA selective glutamate receptor complex	cellular component	IDA[10480938\|17047094]	5
GO:0060079	excitatory postsynaptic potential	biological process	IEA	5
GO:0004972	NMDA glutamate receptor activity	molecular function	IEA	4
GO:0097481	neuronal postsynaptic density	cellular component	IEA	4
GO:0007611	learning or memory	biological process	TAS[10485705]	6
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	11
GO:0009986	cell surface	cellular component	ISS	21
GO:0060291	long-term synaptic potentiation	biological process	IEA	5
GO:0048010	vascular endothelial growth factor receptor signaling pathway	biological process	TAS	9
GO:0007265	Ras protein signal transduction	biological process	TAS	8
GO:0008270	zinc ion binding	molecular function	ISS	26
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	TAS	9
GO:0000186	activation of MAPKK activity	biological process	TAS	7
GO:0007423	sensory organ development	biological process	IEA	1

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in PTSDgene
hsa04720	Long-term potentiation	6
hsa05322	Systemic lupus erythematosus	3
hsa04080	Neuroactive ligand-receptor interaction	22

Gene related interactors from protein-protein interactions data in PINA v2 (count: 23)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
GRIN2B	ARHGAP32	No	--	--	12857875 , 12857875 , 12857875 , 12857875
GRIN2B	LIN7B	No	--	--	10341223 , 10341223 , 10341223
GRIN2B	INADL	No	--	--	9647694
GRIN2B	KDM5B	No	--	--	19336002
GRIN2B	CAMK2N1	No	--	--	12650977
GRIN2B	DLG2	No	--	--	11997254 , 9278515 , 9806853
GRIN2B	MIB2	No	--	--	17962190 , 17962190
GRIN2B	GRIN3A	No	--	--	11588171 , 12391275 , 11588171
GRIN2B	CAMK2B	No	--	--	16436603
GRIN2B	TANC1	No	--	--	15673434
GRIN2B	DLG3	No	--	--	12738960 , 11937501 , 11997254 , 12738960 , 11937501 , 9278515 , 11937501
GRIN2B	AP2M1	No	--	--	15254094
GRIN2B	ERBB2IP	No	--	--	11278603
GRIN2B	EXOC4	No	--	--	12738960 , 12738960 , 12738960
GRIN2B	AP1M1	No	--	--	15254094
GRIN2B	EXOC7	No	--	--	12738960
GRIN2B	CAMK2D	No	--	--	16436603
GRIN2B	MAGI3	No	--	--	10748157 , 10748157 , 10748157 , 10748157 , 10748157 , 10748157 , 10748157
GRIN2B	CAMK2G	No	biochemical	--	9670010 , 16436603
GRIN2B	IL16	No	--	--	10479680 , 10479680
GRIN2B	CAMK2A	No	--	colocalization	16120608 , 16436603 , 11459059 , 19453375 , 19453375 , 19453375
GRIN2B	SYNGAP1	No	--	--	9620694
GRIN2B	SPTAN1	No	biochemical	association	9670010 , 9670010