PTSDgene database

Study Report

Study Information
Basic Info
Reference Xie, P.,2013 PMID: 23726511
Citation Xie, P., et al. (2013). "Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder." Biol Psychiatry 74(9): 656-663.
Phenotype Lifetime PTSD
Trauma Various
Study Design Case-control
Study Type Genome-wide association study
Sample Size 1578 European Americans (EAs) (300 PTSD cases) and 2766 African Americans (AAs) (444 PTSD cases)
SNP/Marker Size EAs: 768,146 SNPs and AAs: 870,103 SNPs, passed quality control steps.
Predominant Ethnicity Caucasian, Black
Population African Americans, European American
Gender Cases:GWAS subjects,African Americans (444) 54.3% female, European Americans (300) 60.3% female; Replication Subjects,African Americans (89) 51.7% female, European Americans (207) 58.5% female. Controls:GWAS subjects,African Americans (2322) 43.1% female, European Americans (1278) 35.4% female; Replication Subjects,African Americans (655) 46.6% female, European Americans (1692) 44.9% female.
Age Cases:GWAS subjects,African Americans, mean age=41.5 years (SD=8.7), European Americans, mean age=37.7 years (SD=9.8); Replication Subjects,African Americans, mean age=41.0 years (SD=9.5), European Americans, mean age=38.4 years (SD=10.8). Controls:GWAS subjects, African Americans mean age=41.2 years (SD=9.3), European Americans, mean age=38.4 years (SD=11.3); Replication Subjects, African Americans, mean age=41.1 years (SD=11.2), European Americans, mean age=39.6 years (SD=13.9).

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 29)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
rs13006863 Lifetime PTSD SLC4A5 Whole Cohort of African Americans: in GWAS,P-value=2.45E-06,in replication,P-value=0.015,in combined, P-value=2.25E-03;Trauma Exposed African Americans: in GWAS,P-value=6.03E-06,in replication,P-value=0.022,in combined, P-value=2.14E-03. No significant signals were observed in the African American...... No significant signals were observed in the African American part of the sample. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More... Trend
rs11909487 Lifetime PTSD USP25 Trauma Exposed African Americans: in GWAS,P-value=1.36E-05,in replication,P-value=NT,in combined, P-value=NT. No significant signals were observed in the African American...... No significant signals were observed in the African American part of the sample. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More... Trend
rs2272651 Lifetime PTSD NDRG1 Whole Cohort of European Americans: in GWAS,P-value=3.10E-06,in replication,P-value=0.76,in combined, P-value=5.36E-05 No significant signals was observed about this SNP. No significant signals was observed about this SNP. Trend
rs2236805 Lifetime PTSD PAX7 Trauma Exposed European Americans: in GWAS,P-value=6.72E-06,in replication,P-value=NT,in combined, P-value=NT. No significant signals was observed about this SNP. Genome-w...... No significant signals was observed about this SNP. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More... Trend
rs16907840 Lifetime PTSD MTRNR2L5 Whole Cohort of European Americans: in GWAS,P-value=7.59E-06,in replication,P-value=NT,in combined, P-value=NT;Trauma Exposed European Americans: in GWAS,P-value=1.58E-05,in replication,P-value=NT,in combined, P-value=NT. No significant signals was observed about this SNP. No significant signals was observed about this SNP. Trend
rs16904179 Lifetime PTSD FAM49B Whole Cohort of African Americans: in GWAS,P-value=5.42E-06,in replication,P-value=NT,in combined, P-value=NT No significant signals were observed in the African American...... No significant signals were observed in the African American part of the sample. More... Trend
rs1503292 Lifetime PTSD TLL1 Whole Cohort of European Americans: in GWAS,P-value=1.71E-06,in replication,P-value=NT,in combined, P-value=NT No significant signals was observed about this SNP. No significant signals was observed about this SNP. Trend
rs1500899 Lifetime PTSD C8orf37 Trauma Exposed African Americans: in GWAS,P-value=9.94E-06,in replication,P-value=NT,in combined, P-value=NT. No significant signals were observed in the African American...... No significant signals were observed in the African American part of the sample. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More... Trend
rs1425392 Lifetime PTSD TECRL Trauma Exposed European Americans: in GWAS,P-value=7.37E-06,in replication,P-value=NT,in combined, P-value=NT. No significant signals was observed about this SNP. Genome-w...... No significant signals was observed about this SNP. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More... Trend
rs9538394 Lifetime PTSD DIAPH3 Trauma Exposed European Americans: in GWAS,P-value=9.12E-06,in replication,P-value=NT,in combined, P-value=NT. No significant signals was observed about this SNP. Genome-w...... No significant signals was observed about this SNP. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More... Trend
rs9923585 Lifetime PTSD ABCC1 Trauma Exposed African Americans: in GWAS,P-value=1.74E-05,in replication,P-value=NT,in combined, P-value=NT. No significant signals were observed in the African American...... No significant signals were observed in the African American part of the sample. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More... Trend
rs7207499 Lifetime PTSD PRKCA Whole Cohort of African Americans: in GWAS,P-value=1.16E-05,in replication,P-value=NT,in combined, P-value=NT No significant signals were observed in the African American...... No significant signals were observed in the African American part of the sample. More... Trend
rs7158872 Lifetime PTSD RPS29 Whole Cohort of African Americans: in GWAS,P-value=2.54E-06,in replication,P-value=NT,in combined, P-value=NT;Trauma Exposed African Americans: in GWAS,P-value=6.02E-06,in replication,P-value=NT,in combined, P-value=NT. No significant signals were observed in the African American...... No significant signals were observed in the African American part of the sample. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More... Trend
rs7691872 Lifetime PTSD TLL1 Whole Cohort of European Americans: in GWAS,P-value=2.22E-06,in replication,P-value=2.30E-04,in combined, P-value=1.22E-07 No significant signals was observed about this SNP. No significant signals was observed about this SNP. Trend
rs382903 Lifetime PTSD COBL Whole Cohort of European Americans: in GWAS,P-value=2.70E-07,in replication,P-value=NT,in combined, P-value=NT;Trauma Exposed European Americans: in GWAS,P-value=6.10E-07,in replication,P-value=NT,in combined, P-value=NT. No significant signals was observed about this SNP. Genome-w...... No significant signals was observed about this SNP. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More... Trend
rs406001 Lifetime PTSD COBL Whole Cohort of European Americans: in GWAS,P-value=3.97E-08,in replication,P-value=0.95,in combined, P-value=2.77E-04;Trauma Exposed European Americans: in GWAS,P-value=1.14E-07,in replication,P-value=0.41,in combined, P-value=3.41E-03. In EAs,they observed that one SNP on chromosome 7p12, rs4060...... In EAs,they observed that one SNP on chromosome 7p12, rs406001, exceeded genome-wide significance. More... Significant
rs4430311 Lifetime PTSD AKT3 Trauma Exposed European Americans: in GWAS,P-value=5.11E-06,in replication,P-value=NT,in combined, P-value=NT. No significant signals was observed about this SNP. Genome-w...... No significant signals was observed about this SNP. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More... Trend
APOB_intron_2-21091512 Lifetime PTSD APOB Whole Cohort of African Americans: in GWAS,P-value=5.07E-06,in replication,P-value=NT,in combined, P-value=NT;Trauma Exposed African Americans: in GWAS,P-value=1.18E-05,in replication,P-value=NT,in combined, P-value=NT. No significant signals were observed in the African American...... No significant signals were observed in the African American part of the sample. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More... Trend
rs4491792 Lifetime PTSD OTOR Whole Cohort of European Americans: in GWAS,P-value=1.57E-06,in replication,P-value=NT,in combined, P-value=NT;Trauma Exposed European Americans: in GWAS,P-value=5.96E-06,in replication,P-value=NT,in combined, P-value=NT. No significant signals was observed about this SNP. Genome-w...... No significant signals was observed about this SNP. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More... Trend
rs2305272 Lifetime PTSD NTM Whole Cohort of African Americans: in GWAS,P-value=4.70E-06,in replication,P-value=NT,in combined, P-value=NT;Trauma Exposed African Americans: in GWAS,P-value=5.22E-06,in replication,P-value=0.41,in combined, P-value=3.41E-03. No significant signals were observed in the African American...... No significant signals were observed in the African American part of the sample. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More... Trend
rs2572096 Lifetime PTSD FBXL4 Trauma Exposed African Americans: in GWAS,P-value=7.07E-06,in replication,P-value=NT,in combined, P-value=NT. No significant signals were observed in the African American...... No significant signals were observed in the African American part of the sample. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More... Trend
rs2779551 Lifetime PTSD GABBR2 Whole Cohort of European Americans: in GWAS,P-value=5.36E-06,in replication,P-value=0.28,in combined, P-value=0.019 No significant signals was observed about this SNP. No significant signals was observed about this SNP. Trend
rs6812849 Lifetime PTSD TLL1 Whole Cohort of European Americans: in GWAS,P-value=2.99E-07,in replication,P-value=6.28E-06,in combined, P-value=3.13E-09;Trauma Exposed European Americans: in GWAS,P-value=2.37E-06,in replication,P-value=1.59E-03,in combined, P-value=1.22E-06. This study identified TLL1 as a new susceptibility gene for ...... This study identified TLL1 as a new susceptibility gene for PTSD. More... Significant
rs6969903 Lifetime PTSD AHR Whole Cohort of African Americans: in GWAS,P-value=1.11E-05,in replication,P-value=NT,in combined, P-value=NT No significant signals were observed in the African American...... No significant signals were observed in the African American part of the sample. More... Trend
rs7014900 Lifetime PTSD TRPS1 Whole Cohort of African Americans: in GWAS,P-value=1.10E-06,in replication,P-value=0.45,in combined, P-value=1.31E-04;Trauma Exposed African Americans: in GWAS,P-value=1.46E-06,in replication,P-value=0.14,in combined, P-value=3.90E-04. No significant signals were observed in the African American...... No significant signals were observed in the African American part of the sample. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More... Trend
rs7076096 Lifetime PTSD GRIN1 Trauma Exposed African Americans: in GWAS,P-value=9.12E-06,in replication,P-value=NT,in combined, P-value=NT. No significant signals were observed in the African American...... No significant signals were observed in the African American part of the sample. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More... Trend
rs450378 Lifetime PTSD COBL Whole Cohort of European Americans: in GWAS,P-value=1.19E-06,in replication,P-value=0.25,in combined, P-value=2.03E-04;Trauma Exposed European Americans: in GWAS,P-value=4.89E-06,in replication,P-value=0.41,in combined, P-value=5.59E-04. No significant signals was observed about this SNP. Genome-w...... No significant signals was observed about this SNP. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More... Trend
rs4955793 Lifetime PTSD ZMAT3 Whole Cohort of African Americans: in GWAS,P-value=1.06E-05,in replication,P-value=NT,in combined, P-value=NT No significant signals were observed in the African American...... No significant signals were observed in the African American part of the sample. More... Trend
rs6589574 Lifetime PTSD SIK3 Whole Cohort of African Americans: in GWAS,P-value=8.73E-06,in replication,P-value=NT,in combined, P-value=NT No significant signals were observed in the African American...... No significant signals were observed in the African American part of the sample. More... Trend

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Last update: April 1, 2018