Gene Report

Basic Info

Approved Symbol	GABBR2
Previous Symbol	GPR51
Symbol Alias	"HG20\|GABABR2\|GPRC3B"
Approved Name	gamma-aminobutyric acid (GABA) B receptor, 2
Previous Name	G protein-coupled receptor 51
Location	9q22.1-q22.3
Position	chr9:98288082-98709197, -1
External Links	HGNC: 4507 Entrez Gene: 9568 Ensembl: ENSG00000136928 UCSC: uc004ays.3
No. of Association Results	1 (Positive: 0; Negative: 0; trend: 1)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Xie, P.,2013	Lifetime PTSD	rs2779551	Trend

Gene functional annotation

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0004965	G-protein coupled GABA receptor activity	molecular function	IDA[9872316]	1
GO:0030054	cell junction	cellular component	IEA	24
GO:0007214	gamma-aminobutyric acid signaling pathway	biological process	IDA[9872316]	4
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0007268	synaptic transmission	biological process	TAS	32
GO:0038039	G-protein coupled receptor heterodimeric complex	cellular component	IPI[9872316]	1
GO:0005887	integral component of plasma membrane	cellular component	IDA[9872316]	36
GO:0007194	negative regulation of adenylate cyclase activity	biological process	TAS[10328880]	5
GO:0005737	cytoplasm	cellular component	IEA	109
GO:0045211	postsynaptic membrane	cellular component	IEA	21
GO:0043005	neuron projection	cellular component	IEA	17
GO:0005515	protein binding	molecular function	IPI[16724110\|24658140]	169
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[9872316]	14

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa04080	Neuroactive ligand-receptor interaction	22

Gene related interactors from protein-protein interactions data in PINA v2 (count: 9)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
GABBR2	ATF4	No	--	--	11087824 , 11087824
GABBR2	HTR1A	Yes	--	--	11854302
GABBR2	ATF5	No	--	--	11087824
GABBR2	GRASP	No	--	--	11850456
GABBR2	GABBR1	No	--	--	16724110 , 16724110 , 10075644 , 16724110 , 9872316 , 9872316 , 9872316
GABBR2	SH3GL3	No	--	--	16169070 , 16169070 , 16169070 , 16169070 , 16169070
GABBR2	NSF	No	--	colocalization	16724110 , 16724110 , 16724110 , 16724110 , 16724110 , 16724110 , 16724110 , 16724110 , 16724110 , 16724110 , 16724110 , 16724110 , 16724110
GABBR2	GLP1R	No	--	--	23864651 , 23864651
GABBR2	CERS2	No	--	--	20195357