SNP Report

Basic Info

Name	rs9923585 dbSNP Ensembl
Location	16:15983503 - 15983503(+)
Variant Seq	C
Ancestral Allele	G
Ref Seq	G
Minor Allele Frequence	0.0131789
Annotation	intron_variant
Variant Effect	intron_variant(ENST00000399410, ENST00000399408)
SIFT Annotation	deleterious; tolerated
SIFT Variant Effect	deleterious(ENST00000575938, ENST00000255759); tolerated(ENST00000573087, ENST00000572415, ENST00000573429, ENST00000575073, ENST00000573396, ENST00000573968)
PolyPhen Annotation	benign; possibly_damaging
PolyPhen Variant Effect	benign(ENST00000573087, ENST00000572415); possibly_damaging(ENST00000575938, ENST00000573429, ENST00000255759, ENST00000575073, ENST00000573396, ENST00000573968)
rSNP?	Yes Link in rVarBase
Related Regulatory Elements	n/a
Chromatin State	Weak transcription;Genic enhancers;Enhancers;ZNF genes & repeats
No. of Marker's Association Results	1 (Positive: 0; Negative: 0; Trend: 1)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Xie, P.,2013	Lifetime PTSD	Trauma Exposed African Americans: in GWAS,P-value=1.74E-05,i...... Trauma Exposed African Americans: in GWAS,P-value=1.74E-05,in replication,P-value=NT,in combined, P-value=NT. More...	No significant signals were observed in the African American...... No significant signals were observed in the African American part of the sample. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More...	Trend

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
ABCC1	ATP binding cassette subfamily C member 1	16p13.1	1(0/0/1)

SNPs in LD with rs9923585 (count: 8)

The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Annotation	r²[population]
rs45479992	rs9923585	intron_variant	1.0000[AFR]
rs9928852	rs9923585	intron_variant	1.0000[AFR]
rs9938526	rs9923585	intron_variant	1.0000[AFR]
rs9935678	rs9923585	intron_variant	1.0000[AFR]
rs13335227	rs9923585	intron_variant	1.0000[AFR]
rs9921168	rs9923585	intron_variant	1.0000[AFR]
rs9932986	rs9923585	intron_variant	1.0000[AFR]
rs28377922	rs9923585	intron_variant	0.9563[AFR]

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
RP11-707O23.5	No	Adipose Subcutaneous	cis	GTEx