Gene Report

Basic Info

Approved Symbol	AHR
Symbol Alias	bHLHe76
Approved Name	aryl hydrocarbon receptor
Location	7p15
Position	chr7:17298622-17346152, 1
External Links	HGNC: 348 Entrez Gene: 196 Ensembl: ENSG00000106546 UCSC: uc011jxz.1
No. of Association Results	1 (Positive: 0; Negative: 0; trend: 1)
Annotation Type	Literature-origin

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Xie, P.,2013	Lifetime PTSD	rs6969903	Trend

Gene functional annotation

Gene related GO terms (count: 41)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0003677	DNA binding	molecular function	IDA[15681594]; TAS[19538249]	13
GO:0001541	ovarian follicle development	biological process	IEA	2
GO:0034752	cytosolic aryl hydrocarbon receptor complex	cellular component	TAS[19538249]	1
GO:0007049	cell cycle	biological process	IEA	7
GO:0010468	regulation of gene expression	biological process	IDA[15681594]	3
GO:0045892	negative regulation of transcription, DNA-templated	biological process	ISS	5
GO:0005737	cytoplasm	cellular component	IDA[15681594]	109
GO:0043565	sequence-specific DNA binding	molecular function	IEA	5
GO:0005667	transcription factor complex	cellular component	TAS[19538249]	3
GO:0044212	transcription regulatory region DNA binding	molecular function	IDA[15681594]	4
GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular function	IEA	1
GO:0006366	transcription from RNA polymerase II promoter	biological process	IDA[10395741]	6
GO:0001568	blood vessel development	biological process	NAS[19538249]	1
GO:0006805	xenobiotic metabolic process	biological process	TAS[19538249]	9
GO:0006355	regulation of transcription, DNA-templated	biological process	IDA[10395741]	14
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IBA	25
GO:0045893	positive regulation of transcription, DNA-templated	biological process	ISS	11
GO:0030522	intracellular receptor signaling pathway	biological process	IDA[10395741]	2
GO:0009410	response to xenobiotic stimulus	biological process	IDA[7961644]	1
GO:0003700	transcription factor activity, sequence-specific DNA binding	molecular function	IDA[11782478]	9
GO:0006915	apoptotic process	biological process	TAS[12213388]	19
GO:0051879	Hsp90 protein binding	molecular function	IDA[9079689]	2
GO:0046982	protein heterodimerization activity	molecular function	TAS[19538249]	10
GO:0070888	E-box binding	molecular function	ISS	2
GO:0032355	response to estradiol	biological process	IEA	9
GO:0005634	nucleus	cellular component	IDA[10395741\|15681594\|23275542]	81
GO:0030850	prostate gland development	biological process	IEA	1
GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	biological process	IEA	1
GO:0009636	response to toxic substance	biological process	IDA[7961644]	10
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	IDA[15681594]	5
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IEA	16
GO:0005654	nucleoplasm	cellular component	IDA	43
GO:0034753	nuclear aryl hydrocarbon receptor complex	cellular component	IBA	1
GO:0046983	protein dimerization activity	molecular function	TAS[19538249]	5
GO:0032922	circadian regulation of gene expression	biological process	ISS	4
GO:0004879	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding	molecular function	IDA[10395741]	2
GO:0071385	cellular response to glucocorticoid stimulus	biological process	IEA	3
GO:0030888	regulation of B cell proliferation	biological process	IDA[15681594]	1
GO:0005515	protein binding	molecular function	IPI[9079689\|9704006\|10395741\|16257957]	169
GO:0008134	transcription factor binding	molecular function	IPI[9079689]	5
GO:0035326	enhancer binding	molecular function	IDA[23275542]	1

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 22)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
AHR	CUL4B	No	--	--	19651607 , 17392787 , 17392787
AHR	EP300	No	--	--	10999956 , 10999956 , 21988832 , 21988832
AHR	BRCA1	No	--	--	18259752 , 18259752 , 18259752
AHR	SMARCA4	No	--	--	11805098 , 11805098
AHR	DDB1	No	--	--	19651607 , 19651607 , 19651607 , 17392787
AHR	NCOA1	No	--	--	15641800 , 12024042
AHR	SUMO2	No	--	--	21693764
AHR	RELA	No	--	--	11114727 , 12181450 , 12181450
AHR	STUB1	No	--	--	17209571 , 12837759
AHR	TAF6	No	--	--	15641800
AHR	PTGES3	No	--	--	11259606
AHR	TAF7	No	--	--	8794892
AHR	NCOR2	No	coimmunoprecipitation	--	10395741 , 10395741 , 10395741 , 10395741 , 10395741
AHR	NCOA7	No	coimmunoprecipitation	--	10395741 , 10395741 , 10395741 , 10395741
AHR	FOXA1	No	--	colocalization	22596188 , 22596188
AHR	NFE2L2	No	--	colocalization	20395535
AHR	NEDD8	No	--	--	12215427 , 12215427 , 12215427
AHR	DAP3	No	--	--	10903152 , 10903152
AHR	IVNS1ABP	No	--	--	16582008 , 16582008
AHR	NRIP1	No	--	--	10428779 , 10428779 , 10428779
AHR	TAF9	No	--	--	15641800
AHR	NCOA2	No	--	--	12024042 , 15641800 , 15641800