Gene Report

Basic Info

Approved Symbol	GRIN1
Previous Symbol	NMDAR1
Symbol Alias	GluN1
Approved Name	glutamate receptor, ionotropic, N-methyl D-aspartate 1
Previous Name	N-methyl-D-aspartate receptor subunit NR1
Location	9q34.3
Position	chr9:137138390-137168762, 1
External Links	HGNC: 4584 Entrez Gene: 2902 Ensembl: ENSG00000176884 UCSC: uc004cln.3
No. of Association Results	1 (Positive: 0; Negative: 0; trend: 1)
Annotation Type	Literature-origin

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Xie, P.,2013	Lifetime PTSD	rs7076096	Trend

Gene functional annotation

Gene related GO terms (count: 86)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0030425	dendrite	cellular component	IDA[10749211]	19
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	11
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	ISS	25
GO:0060079	excitatory postsynaptic potential	biological process	ISS	5
GO:0060076	excitatory synapse	cellular component	ISS	1
GO:0045211	postsynaptic membrane	cellular component	ISS	21
GO:0060179	male mating behavior	biological process	IEA	1
GO:0043083	synaptic cleft	cellular component	ISS	1
GO:0001967	suckling behavior	biological process	IEA	3
GO:0008286	insulin receptor signaling pathway	biological process	TAS	8
GO:0045087	innate immune response	biological process	TAS	15
GO:0007265	Ras protein signal transduction	biological process	TAS	8
GO:0009986	cell surface	cellular component	ISS	21
GO:0043065	positive regulation of apoptotic process	biological process	IEA	12
GO:0001975	response to amphetamine	biological process	IEA	9
GO:0042391	regulation of membrane potential	biological process	IDA[7679115\|7685113\|17047094]	4
GO:0048511	rhythmic process	biological process	IEA	3
GO:0005515	protein binding	molecular function	IPI[11937501\|17047094\|17997397]	169
GO:0034765	regulation of ion transmembrane transport	biological process	IEA	2
GO:0019899	enzyme binding	molecular function	IEA	13
GO:0043197	dendritic spine	cellular component	ISS	9
GO:0018964	propylene metabolic process	biological process	ISS	1
GO:0016595	glutamate binding	molecular function	IDA[7685113]	1
GO:2000463	positive regulation of excitatory postsynaptic potential	biological process	ISS	4
GO:0008344	adult locomotory behavior	biological process	IEA	2
GO:0043025	neuronal cell body	cellular component	IEA	18
GO:0048169	regulation of long-term neuronal synaptic plasticity	biological process	IEA	2
GO:0055074	calcium ion homeostasis	biological process	ISS	1
GO:0042165	neurotransmitter binding	molecular function	ISS	1
GO:0048013	ephrin receptor signaling pathway	biological process	TAS	3
GO:0007411	axon guidance	biological process	TAS	16
GO:0007585	respiratory gaseous exchange	biological process	IEA	2
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS	11
GO:0051963	regulation of synapse assembly	biological process	IEA	1
GO:0070588	calcium ion transmembrane transport	biological process	IDA[7685113]	5
GO:0005516	calmodulin binding	molecular function	ISS	4
GO:0035176	social behavior	biological process	IEA	9
GO:0000186	activation of MAPKK activity	biological process	TAS	7
GO:0006874	cellular calcium ion homeostasis	biological process	IEA	9
GO:0005887	integral component of plasma membrane	cellular component	IDA[7685113]	36
GO:0045471	response to ethanol	biological process	IDA[18445116]	18
GO:0008355	olfactory learning	biological process	IEA	2
GO:0060134	prepulse inhibition	biological process	IEA	4
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	TAS	9
GO:0022843	voltage-gated cation channel activity	molecular function	IEA	1
GO:0008542	visual learning	biological process	ISS	6
GO:0006812	cation transport	biological process	IDA[7685113]	1
GO:0008021	synaptic vesicle	cellular component	ISS	6
GO:0001661	conditioned taste aversion	biological process	IEA	1
GO:0043005	neuron projection	cellular component	ISS	17
GO:0007268	synaptic transmission	biological process	TAS	32
GO:0051262	protein tetramerization	biological process	IEA	6
GO:0048814	regulation of dendrite morphogenesis	biological process	IEA	3
GO:0005234	extracellular-glutamate-gated ion channel activity	molecular function	IEA	4
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0051592	response to calcium ion	biological process	IEA	4
GO:0048010	vascular endothelial growth factor receptor signaling pathway	biological process	TAS	9
GO:0019233	sensory perception of pain	biological process	IEA	9
GO:0004972	NMDA glutamate receptor activity	molecular function	IDA[7679115\|7685113]	4
GO:0005509	calcium ion binding	molecular function	ISS	9
GO:0043576	regulation of respiratory gaseous exchange	biological process	IEA	1
GO:0038095	Fc-epsilon receptor signaling pathway	biological process	TAS	8
GO:0043195	terminal bouton	cellular component	ISS	7
GO:0007616	long-term memory	biological process	IEA	3
GO:0044307	dendritic branch	cellular component	IEA	1
GO:0071287	cellular response to manganese ion	biological process	IEA	2
GO:0097481	neuronal postsynaptic density	cellular component	IEA	4
GO:0060992	response to fungicide	biological process	IEA	1
GO:0021987	cerebral cortex development	biological process	IEA	5
GO:0005262	calcium channel activity	molecular function	IDA[7685113]	3
GO:0035249	synaptic transmission, glutamatergic	biological process	IEA	2
GO:0045202	synapse	cellular component	ISS	7
GO:0035254	glutamate receptor binding	molecular function	IEA	1
GO:0005783	endoplasmic reticulum	cellular component	IEA	20
GO:0007264	small GTPase mediated signal transduction	biological process	TAS	14
GO:0043524	negative regulation of neuron apoptotic process	biological process	IEA	4
GO:0016594	glycine binding	molecular function	IDA[7685113]; IMP[17047094]	2
GO:0021586	pons maturation	biological process	IEA	1
GO:0050770	regulation of axonogenesis	biological process	IEA	1
GO:0017146	NMDA selective glutamate receptor complex	cellular component	IDA[7679115\|10480938\|17047094]	5
GO:0014069	postsynaptic density	cellular component	ISS	11
GO:0043278	response to morphine	biological process	IEA	6
GO:0000165	MAPK cascade	biological process	TAS	10
GO:0035235	ionotropic glutamate receptor signaling pathway	biological process	ISS	5
GO:0030054	cell junction	cellular component	IEA	24
GO:0046982	protein heterodimerization activity	molecular function	IEA	10

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in PTSDgene
hsa04720	Long-term potentiation	6
hsa04020	Calcium signaling pathway	11
hsa04080	Neuroactive ligand-receptor interaction	22

Gene related interactors from protein-protein interactions data in PINA v2 (count: 21)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
GRIN1	SPTAN1	No	biochemical	association	9670010 , 9670010 , 9670010
GRIN1	CAMK2G	No	biochemical	--	9670010
GRIN1	GRIN2B	Yes	--	--	8139656 , 12391275 , 11588171
GRIN1	PLCB4	No	--	--	16767099
GRIN1	INA	No	--	--	10862698
GRIN1	TJP1	No	--	--	10862698
GRIN1	TRAF3	No	--	--	10862698
GRIN1	GRIN2A	Yes	--	--	12391275
GRIN1	DLGAP4	No	--	--	10862698
GRIN1	LRP8	No	--	--	16332682
GRIN1	DLG3	No	--	--	10862698
GRIN1	CAMK2A	No	--	--	10862698
GRIN1	DLG2	No	--	--	10862698
GRIN1	SYNGAP1	No	--	--	10862698
GRIN1	CACNG2	No	--	colocalization	11140673
GRIN1	LNX1	No	--	--	22889411 , 22889411
GRIN1	GRIN3A	No	--	--	12391275 , 11588171 , 11588171
GRIN1	NANOS1	No	--	--	10862698
GRIN1	DUSP4	No	--	--	10862698
GRIN1	ERBB4	No	--	--	16767099 , 16767099
GRIN1	AKAP9	No	--	--	9482789