Gene Report

Basic Info

Approved Symbol	NDRG1
Previous Symbol	CAP43
Symbol Alias	"DRG1\|RTP\|TDD5\|NDR1"
Approved Name	N-myc downstream regulated 1
Location	8q24
Position	chr8:133237171-133302022, -1
External Links	HGNC: 7679 Entrez Gene: 10397 Ensembl: ENSG00000104419 UCSC: uc003yug.2
No. of Association Results	1 (Positive: 0; Negative: 0; trend: 1)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Xie, P.,2013	Lifetime PTSD	rs2272651	Trend

Gene functional annotation

Gene related GO terms (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[17786215]	14
GO:0017137	Rab GTPase binding	molecular function	IDA[17786215]	4
GO:0005913	cell-cell adherens junction	cellular component	IDA[12432451]	2
GO:0071456	cellular response to hypoxia	biological process	IEP[20810912]	4
GO:0032287	peripheral nervous system myelin maintenance	biological process	IEA	1
GO:0005515	protein binding	molecular function	IPI[15607035\|17220478\|17786215\|25416956]	169
GO:0030330	DNA damage response, signal transduction by p53 class mediator	biological process	IEP[9766676]	2
GO:0070062	extracellular exosome	cellular component	IDA[19056867\|23376485]	58
GO:0015630	microtubule cytoskeleton	cellular component	IDA	2
GO:0090232	positive regulation of spindle checkpoint	biological process	IDA[15247272]	1
GO:0010038	response to metal ion	biological process	TAS[9605764]	1
GO:0008285	negative regulation of cell proliferation	biological process	IEA	13
GO:0005874	microtubule	cellular component	IDA[15247272]	8
GO:0005886	plasma membrane	cellular component	IDA[12432451]	99
GO:0005737	cytoplasm	cellular component	IDA[9766676]	109
GO:0045576	mast cell activation	biological process	IEA	1
GO:0055038	recycling endosome membrane	cellular component	IDA[17786215]	1
GO:0005829	cytosol	cellular component	IEA	78
GO:0045296	cadherin binding	molecular function	IDA[17786215]	4
GO:0005813	centrosome	cellular component	IDA[15247272]	9
GO:0008017	microtubule binding	molecular function	IDA[15247272]	6
GO:0043015	gamma-tubulin binding	molecular function	IDA[15247272]	2
GO:0043209	myelin sheath	cellular component	IEA	1
GO:0005634	nucleus	cellular component	IDA[9766676]	81

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 7)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
NDRG1	UPF1	No	--	--	17220478 , 17220478 , 17220478
NDRG1	DPP3	No	biochemical	colocalization	22863883
NDRG1	RUVBL2	No	--	--	17220478 , 17220478 , 17220478
NDRG1	CNDP2	No	--	--	17220478 , 17220478 , 17220478
NDRG1	AP1M2	No	--	--	17220478 , 17220478 , 17220478
NDRG1	FTO	No	biochemical	colocalization	22863883
NDRG1	AP2M1	No	--	--	17220478 , 17220478 , 17220478