Gene Report

Basic Info

Approved Symbol	AKT3
Symbol Alias	"PKBG\|RAC-gamma\|PRKBG"
Approved Name	v-akt murine thymoma viral oncogene homolog 3
Name Alias	protein kinase B, gamma
Location	1q44
Position	chr1:243488233-243851079, -1
External Links	HGNC: 393 Entrez Gene: 10000 Ensembl: ENSG00000117020 UCSC: uc001iab.2
No. of Association Results	1 (Positive: 0; Negative: 0; trend: 1)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Xie, P.,2013	Lifetime PTSD	rs4430311	Trend

Gene functional annotation

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0005886	plasma membrane	cellular component	IDA	99
GO:0005515	protein binding	molecular function	IPI[12176997\|17544405\|19713527\|20059950\|25036637\|25241761]	169
GO:0004672	protein kinase activity	molecular function	TAS[10092583]	3
GO:0005737	cytoplasm	cellular component	IDA	109
GO:0004674	protein serine/threonine kinase activity	molecular function	IDA[16540465]	5
GO:0005794	Golgi apparatus	cellular component	IDA	17
GO:0005524	ATP binding	molecular function	IDA[16540465]	23
GO:0035556	intracellular signal transduction	biological process	IBA	10
GO:0007165	signal transduction	biological process	IMP[18524868]	34
GO:0018105	peptidyl-serine phosphorylation	biological process	IBA	3
GO:0005654	nucleoplasm	cellular component	IDA	43
GO:0000002	mitochondrial genome maintenance	biological process	IMP[18524868]	1
GO:0005622	intracellular	cellular component	IBA	15
GO:0006468	protein phosphorylation	biological process	TAS[10092583]	7

Gene related KEGG pathways (count: 25)

ID	Name	No. of Genes in PTSDgene
hsa04662	B cell receptor signaling pathway	1
hsa04664	Fc epsilon RI signaling pathway	3
hsa04630	Jak-STAT signaling pathway	5
hsa04660	T cell receptor signaling pathway	3
hsa04910	Insulin signaling pathway	1
hsa04920	Adipocytokine signaling pathway	4
hsa05212	Pancreatic cancer	3
hsa05211	Renal cell carcinoma	1
hsa05214	Glioma	3
hsa05213	Endometrial cancer	2
hsa05210	Colorectal cancer	2
hsa05221	Acute myeloid leukemia	1
hsa05222	Small cell lung cancer	5
hsa05220	Chronic myeloid leukemia	2
hsa04010	MAPK signaling pathway	13
hsa05218	Melanoma	2
hsa05215	Prostate cancer	3
hsa04012	ErbB signaling pathway	2
hsa05223	Non-small cell lung cancer	3
hsa04210	Apoptosis	6
hsa04150	mTOR signaling pathway	1
hsa04510	Focal adhesion	6
hsa04370	VEGF signaling pathway	2
hsa04620	Toll-like receptor signaling pathway	3
hsa04530	Tight junction	3

Gene related interactors from protein-protein interactions data in PINA v2 (count: 0)