PTSDgene database

SNP Report

Basic Info
Name rs6269 dbSNP Ensembl
Location 22:19962429 - 19962429(+)
Variant Seq G
Ancestral Allele G
Ref Seq A
Minor Allele Frequence 0.356829
Annotation 5_prime_UTR_variant; upstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
Variant Effect 5_prime_UTR_variant(ENST00000403710); upstream_gene_variant(ENST00000493893, ENST00000449653, ENST00000428707, ENST00000585066); intron_variant(ENST00000407537, ENST00000467943, ENST00000207636, ENST00000412786, ENST00000361682, ENST00000403184, ENST00000406520); NMD_transcript_variant(ENST00000207636); non_coding_transcript_variant(ENST00000467943)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000361682, ENST00000412786, ENST00000403184, ENST00000403710, ENST00000449653, ENST00000207636, ENST00000406520, ENST00000407537)
PolyPhen Annotation benign
PolyPhen Variant Effect benign(ENST00000361682, ENST00000412786, ENST00000403184, ENST00000403710, ENST00000449653, ENST00000207636, ENST00000406520, ENST00000407537)
rSNP? No Link in rVarBase
Related Regulatory Elements N.A.
Chromatin State N.A.
No. of Marker's Association Results 4 (Positive: 0; Negative: 4; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 4)
Reference Phenotype Statistical Values Author Comments Marker's Category
Goenjian, A. K.,2014 B category score Trait DSM-IV based and DSM-V based: both with P-value>0.05. Trait DSM-IV based and DSM-V based: both with P-value>0.05. There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More... Non-significant
Goenjian, A. K.,2014 C category score Trait DSM-IV based and DSM-V based: both with P-value>0.05. Trait DSM-IV based and DSM-V based: both with P-value>0.05. There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More... Non-significant
Goenjian, A. K.,2014 D category score Trait DSM-IV based and DSM-V based: both with P-value>0.05. Trait DSM-IV based and DSM-V based: both with P-value>0.05. There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More... Non-significant
Goenjian, A. K.,2014 Total PTSD symptom severity score Trait DSM-IV based and DSM-V based: both with P-value>0.05. Trait DSM-IV based and DSM-V based: both with P-value>0.05. There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More... Non-significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
COMT catechol-O-methyltransferase 22q11.21 21(9/12/0)

SNPs in LD with rs6269 (count: 7)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 1)

LD-proxies (count: 6)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
FBLL1 No Adipose Subcutaneous cis GTEx