PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Goenjian, A. K.,2014 PMID: 25451452
Citation	Goenjian, A. K., et al. (2014). "Association of COMT and TPH-2 genes with DSM-5 based PTSD symptoms." J Affect Disord 172C: 472-478.
Phenotype	Total PTSD symptom severity score, B category score, C category score, D category score
Trauma	1988 Spitak earthquake
Study Design	Pedigree-based
Study Type	Candidate gene association study
Sample Size	200 adults
SNP/Marker Size	4 SNPs
Predominant Ethnicity	Caucasian
Population	Armenian
Gender	79 males, 121 females
Age	No detial information (adults).

Detail Info

Sample Diagnosis	DSM-IV, DSM-5
Related Diagnostic Tools	An earthquake exposure profile was completed for each participant using a modified version of a DSM IV-based exposure questionnaire previously utilized in studies after disasters (Goenjian et al., 2001 and Roussos et al., 2005). UCLA PTSD Reaction Index (PTSD-RI), modified version of the PTSD-RI based on DSM-5 symptom criteria, Beck Depression Inventory (BDI)
Sample Status	Subjects were recruited from Gumri (a city in Armenia nearby the epicenter of the catastrophic 1988 Spitak earthquake) where there was extensive destruction, morbidity and mortality. 12 multigenerational (three to five generations) families participated and completed the study procedures approximately 14 years post-earthquake.
Controls Exposed	Yes
Replication Size	None
Result Summary	The adjusted heritabilitiy of vulnerability to DSM-5 based PTSD symptoms was 0.60 (P-value<10?4). There was a significant association of the COMT allele rs4633C with total PTSD (P-value<0.03), and D category (P-value<0.04) (negative alterations in cognitions and mood) severity scores, but not with C category (avoidance) scores. There was no genetic correlation between C and D category severity scores. COMT allele rs4633C and the TPH-2 allele rs11178997T together accounted for 7% of the variance in PTSD severity scores (P-value<0.001). None of the COMT alleles were associated with depression. COMT allele rs4633C may be causally related and/or is in linkage disequilibrium with gene(s) that are causally related to PTSD symptoms. Carriers of these COMT and the TPH-2 alleles may be at increased risk for PTSD. The findings provide biological support for dividing DSM-IV category C symptoms into DSM-5 categories C and D.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 16)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs6269	Total PTSD symptom severity score	COMT	Trait DSM-IV based and DSM-V based: both with P-value>0.05.	There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More...	Non-significant
rs4818	Total PTSD symptom severity score	COMT	Trait DSM-IV based and DSM-V based: both with P-value>0.05.	There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More...	Non-significant
rs4680	Total PTSD symptom severity score	COMT	The association of the G allele (Val) and total PTSD severity scores: P-value=0.07 on both DSM IV and DSM-5 based measures.	Regarding the non-synonymous SNP rs4680 (Val158Met), there w...... Regarding the non-synonymous SNP rs4680 (Val158Met), there was a trend toward significance for the association of the G allele (Val) and total PTSD severity scores on both DSM IV and DSM-5 based measures. More...	Non-significant
rs4633	Total PTSD symptom severity score	COMT	Trait DSM-IV based and DSM-V based: both with P-value<0.03.	The COMT SNP allele rs4633C was significantly associated wit...... The COMT SNP allele rs4633C was significantly associated with both DSM-IV and DSM-5 total PTSD severity scores. More...	Significant
rs4818	B category score	COMT	Trait DSM-IV based and DSM-V based: both with P-value>0.05.	There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More...	Non-significant
rs6269	B category score	COMT	Trait DSM-IV based and DSM-V based: both with P-value>0.05.	There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More...	Non-significant
rs4633	B category score	COMT	Trait DSM-IV based and DSM-V based: both with P-value=0.28.	There was no significant association between rs4633C and B c...... There was no significant association between rs4633C and B category score for both scales. More...	Non-significant
rs4680	B category score	COMT	Trait DSM-IV based and DSM-V based: both with P-value>0.05.	There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More...	Non-significant
rs4633	D category score	COMT	DSM-V based: category D scores (negative alterations in cognitions and mood): P-value<0.04.	There was a significant association between rs4633C and cate...... There was a significant association between rs4633C and category D scores (negative alterations in cognitions and mood). More...	Significant
rs4818	C category score	COMT	Trait DSM-IV based and DSM-V based: both with P-value>0.05.	There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More...	Non-significant
rs4680	D category score	COMT	Trait DSM-IV based and DSM-V based: both with P-value>0.05.	There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More...	Non-significant
rs6269	C category score	COMT	Trait DSM-IV based and DSM-V based: both with P-value>0.05.	There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More...	Non-significant
rs4818	D category score	COMT	Trait DSM-IV based and DSM-V based: both with P-value>0.05.	There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More...	Non-significant
rs4633	C category score	COMT	DSM-IV based category C (avoidance/numbing) scores: P-value=0.03, with DSM-5 category C (avoidance) scores: P-value=0.46.	There was a significant association of rs4633C with DSM IV b...... There was a significant association of rs4633C with DSM IV based category C (avoidance/numbing) scores, although not with DSM-5 category C (avoidance) scores. More...	Significant
rs6269	D category score	COMT	Trait DSM-IV based and DSM-V based: both with P-value>0.05.	There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More...	Non-significant
rs4680	C category score	COMT	Trait DSM-IV based and DSM-V based: both with P-value>0.05.	There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More...	Non-significant