Study Report
Study Information
Basic Info
| Reference |
Valente, N. L.,2011 PMID: 21080103
|
| Citation |
Valente, N. L., et al. (2011). "Catechol-O-methyltransferase (COMT) val158met polymorphism as a risk factor for PTSD after urban violence." J Mol Neurosci 43(3): 516-523. |
| Phenotype |
PTSD, CAPS scores |
| Trauma |
Urban violence |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
65 PTSD and 34 victims of violence without PTSD, and 335 in a community control group. |
| SNP/Marker Size |
1 SNP |
| Predominant Ethnicity |
Caucasian |
| Population |
Brazilian |
| Gender |
Cases (n=65):33.3% male. Controls (n=34):17.6% male. More details information about the community control group you can find at PROGENE (Genetic and Pharamcogenetics Program, University of S?o Paulo) data bank. |
| Age |
PTSD+: mean age=37.9 years (SD=8.7); PTSD-: mean age=44 years (SD=13.8). More details information about the community control group you can find at PROGENE (Genetic and Pharamcogenetics Program, University of S?o Paulo) data bank. |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
The interview was administered to all patients by a trained psychiatrist. The Structured Clinical Interview for DSM-IV Axis I and Axis II (SCID-I and -II; Spitzer et al. 1992);Clinician Administered PTSD Scale (CAPS);Beck Anxiety Inventory (BAI);Beck Depression Inventory (BDI); Early Trauma Inventory (ETI). |
| Sample Status |
The presence of lifetime history of bipolar disorder, psychotic disorders, and the presence of substance dependence or abuse disorders(excluding nicotine and caffeine) in the previous 6 months were exclusion criteria. The community control group consisted of 335 subjects from the PROGENE (Genetic and Pharamcogenetics Program, University of S?o Paulo) data bank, which were genotyped controls for the Val/Met COMT gene. |
| Controls Exposed |
VA |
| Replication Size |
None |
| Result Summary |
We found a significant relationship between the met allele (P-value<0.02) and PTSD among cases (PTSD+)and victims of violence without PTSD (PTSD-; OR=2.57) and between cases and community control group (P-value<0.003). Further analysis with larger samples and another ethnic group should be necessary to confirm our findings. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 2)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs4680
|
PTSD |
COMT |
Met allele and PTSD among cases (PTSD+) and victims of violence without PTSD (PTSD-; OR=2.57): P-value<0.02;between cases and community control group P-value<0.003. |
We found a significant relationship between the met allele a......
We found a significant relationship between the met allele and PTSD among cases (PTSD+) and victims of violence without PTSD (PTSD-) and between cases and community control group. Further analysis with larger samples and another ethnic group should be necessary to confirm our findings.
More...
|
Significant |
|
rs4680
|
CAPS scores |
COMT |
Statistical analysis of the genotype and clinical measurements scores: [MET/MET=59.5(SD=31.6); VAL/MET=59.7(SD=27.5); VAL/VAL=44.8(SD=30.8); P-value=0.0353]. Met carriers (homozygote and heterozygote): P-value=0.01. |
It was observed that CAPS score was the only measure that ha......
It was observed that CAPS score was the only measure that had a statistical significance related to COMT val158met genotype. And with higher significance when considered Met carriers (homozygote and heterozygote).
More...
|
Significant |
