Study Report
Study Information
Basic Info
| Reference |
Hayes, J. P.,2017 PMID: 28234210
|
| Citation |
Hayes, J. P., et al. (2017). "COMT Val158Met polymorphism moderates the association between PTSD symptom severity and hippocampal volume." J Psychiatry Neurosci 42(2): 95-102. |
| Phenotype |
PTSD severity |
| Trauma |
Combat |
| Study Design |
Cross-sectional study |
| Study Type |
Candidate gene association study |
| Sample Size |
146 samples |
| SNP/Marker Size |
1 SNP |
| Predominant Ethnicity |
Caucasian |
| Population |
American |
| Gender |
135 males, 11 females |
| Age |
Mean age=32.08 years,SD=8.358 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Clinician Administered PTSD Scale (CAPS), Structured Clinical Interview for DSM-IV (SCID-IV) |
| Sample Status |
Individuals were excluded if their medical history included vascular disease, cardiac conditions, seizures, cognitive disorders not due to traumatic brain injury (TBI), moderate or severe TBI, homicidal or suicidal ideation requiring intervention, or a current psychotic disorder (e.g., schizophrenia, bipolar disorder) based on a DSM-IV diagnosis. |
| Controls Exposed |
NA |
| Replication Size |
None |
| Result Summary |
A significant genotype x PTSD symptom severity interaction emerged such that individuals with greater current PTSD symptom severity who were homozygous for the Val allele showed significant reductions in left hippocampal volume. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs4680
|
CAPS score |
COMT |
F(2,143)=1.05, P-value=0.35 |
Different genotype groups did not differ significantly in CA......
Different genotype groups did not differ significantly in CAPS score.
More...
|
Non-significant |
