PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation van Rooij, S. J., et al. (2016). "Childhood Trauma and COMT Genotype Interact to Increase Hippocampal Activation in Resilient Individuals." Front Psychiatry 7: 156.
Phenotype PTSD symptom severity, PTSD intrusive symptoms, PTSD avoidance/numbing symptoms, PTSD hyperarousal symptoms.
Trauma Various
Study Design Cross-sectional study
Study Type Candidate gene association study
Sample Size 116 samples
SNP/Marker Size 1 SNP
Predominant Ethnicity Black
Population American
Gender 0 males, 116 females
Age Val/Val group: mean age=36.4 years,SD=12.7. Met carrier group: mean age=38.6 years,SD=12.0.

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 4)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
rs4680 PTSD hyperarousal symptoms COMT t(71)=-0.95, P-value=0.35 The symptoms didn't differ between different genotypes. The symptoms didn't differ between different genotypes. Non-significant
rs4680 PTSD symptom severity COMT t(71)=-0.55, P-value=0.58 The symptoms didn't differ between different genotypes. The symptoms didn't differ between different genotypes. Non-significant
rs4680 PTSD avoidance/numbing symptoms COMT t(71)=0.22, P-value=0.82 The symptoms didn't differ between different genotypes. The symptoms didn't differ between different genotypes. Non-significant
rs4680 PTSD intrusive symptoms COMT t(71)=-1.19, P-value=0.24 The symptoms didn't differ between different genotypes. The symptoms didn't differ between different genotypes. Non-significant