PTSDgene database

SNP Report

Basic Info
Name rs4818 dbSNP Ensembl
Location 22:19963684 - 19963684(+)
Variant Seq G,T
Ancestral Allele G
Ref Seq C
Minor Allele Frequence 0.296925
Annotation downstream_gene_variant; synonymous_variant; non_coding_transcript_exon_variant; upstream_gene_variant; NMD_transcript_variant; non_coding_transcript_variant
Variant Effect downstream_gene_variant(ENST00000467943); synonymous_variant(ENST00000406520, ENST00000412786, ENST00000403710, ENST00000361682, ENST00000449653, ENST00000407537, ENST00000207636, ENST00000403184); non_coding_transcript_exon_variant(ENST00000493893); upstream_gene_variant(ENST00000428707, ENST00000585066); NMD_transcript_variant(ENST00000207636); non_coding_transcript_variant(ENST00000493893)
SIFT Annotation deleterious
SIFT Variant Effect deleterious(ENST00000403184, ENST00000361682, ENST00000412786, ENST00000407537, ENST00000207636, ENST00000403710, ENST00000406520)
PolyPhen Annotation probably_damaging; possibly_damaging
PolyPhen Variant Effect probably_damaging(ENST00000207636); possibly_damaging(ENST00000403184, ENST00000361682, ENST00000412786, ENST00000407537, ENST00000403710, ENST00000406520)
rSNP? No Link in rVarBase
Related Regulatory Elements N.A.
Chromatin State N.A.
No. of Marker's Association Results 4 (Positive: 0; Negative: 4; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 4)
Reference Phenotype Statistical Values Author Comments Marker's Category
Goenjian, A. K.,2014 B category score Trait DSM-IV based and DSM-V based: both with P-value>0.05. Trait DSM-IV based and DSM-V based: both with P-value>0.05. There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More... Non-significant
Goenjian, A. K.,2014 C category score Trait DSM-IV based and DSM-V based: both with P-value>0.05. Trait DSM-IV based and DSM-V based: both with P-value>0.05. There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More... Non-significant
Goenjian, A. K.,2014 D category score Trait DSM-IV based and DSM-V based: both with P-value>0.05. Trait DSM-IV based and DSM-V based: both with P-value>0.05. There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More... Non-significant
Goenjian, A. K.,2014 Total PTSD symptom severity score Trait DSM-IV based and DSM-V based: both with P-value>0.05. Trait DSM-IV based and DSM-V based: both with P-value>0.05. There was no significant association between this SNP and su...... There was no significant association between this SNP and subcategory scores, and either of the total PTSD scores. More... Non-significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
COMT catechol-O-methyltransferase 22q11.21 21(9/12/0)

SNPs in LD with rs4818 (count: 6)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 1)

LD-proxies (count: 5)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
FBLL1 No Adipose Subcutaneous cis GTEx