PTSDgene database

Study Report

Study Information
Basic Info
Citation Winkler, E. A., et al. (2017). "COMT Val(158)Met polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury." J Clin Neurosci 35: 109-116.
Phenotype PTSD diagnosis
Trauma Mild traumatic brain injury
Study Design Pilot study
Study Type Candidate gene association study
Sample Size 93 samples
SNP/Marker Size 1 SNP
Predominant Ethnicity Caucasian, Black
Population American
Gender 56 males, 37 females
Age Mean age=40 years

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
rs4680 PTSD diagnosis COMT OR=0.25, P-value=0.006. After controlling for pre-existing psychiatric disorders and substance abuse: OR=0.32, P-value=0.044. COMT Met 158 allele is associated with lower incidence of PT...... COMT Met 158 allele is associated with lower incidence of PTSD. This genotype and PTSD association persists after controlling for race and pre-existing psychiatric disorders/substance abuse. More... Significant