Study Report
Study Information
Basic Info
| Reference | Winkler, E. A.,2017 PMID: 27769642 |
|---|---|
| Citation | Winkler, E. A., et al. (2017). "COMT Val(158)Met polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury." J Clin Neurosci 35: 109-116. |
| Phenotype | PTSD diagnosis |
| Trauma | Mild traumatic brain injury |
| Study Design | Pilot study |
| Study Type | Candidate gene association study |
| Sample Size | 93 samples |
| SNP/Marker Size | 1 SNP |
| Predominant Ethnicity | Caucasian, Black |
| Population | American |
| Gender | 56 males, 37 females |
| Age | Mean age=40 years |
Detail Info
Genetic result reported by this study
| Marker | Phenotype | Related Gene | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|---|
| rs4680 | PTSD diagnosis | COMT | OR=0.25, P-value=0.006. After controlling for pre-existing psychiatric disorders and substance abuse: OR=0.32, P-value=0.044. | COMT Met 158 allele is associated with lower incidence of PT...... COMT Met 158 allele is associated with lower incidence of PTSD. This genotype and PTSD association persists after controlling for race and pre-existing psychiatric disorders/substance abuse. More... | Significant |