PTSDgene database

SNP Report

Basic Info
Name rs10170218 dbSNP Ensembl
Location 2:187949717 - 187949717(+)
Variant Seq C
Ancestral Allele A
Ref Seq A
Minor Allele Frequence 0.276158
Annotation intron_variant; non_coding_transcript_variant
Variant Effect intron_variant(ENST00000434418); non_coding_transcript_variant(ENST00000434418)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000339091, ENST00000421427, ENST00000392365, ENST00000409676, ENST00000437725, ENST00000420747, ENST00000233156, ENST00000453013, ENST00000426055, ENST00000417013, ENST00000435414)
PolyPhen Annotation benign; possibly_damaging
PolyPhen Variant Effect benign(ENST00000421427, ENST00000392365, ENST00000437725, ENST00000420747, ENST00000233156, ENST00000453013, ENST00000426055, ENST00000417013, ENST00000435414); possibly_damaging(ENST00000339091, ENST00000409676)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription
No. of Marker's Association Results 2 (Positive: 1; Negative: 1; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 2)
Reference Phenotype Statistical Values Author Comments Marker's Category
Ashley-Koch, A. E.,2015 Current PTSD In NHB P-value=0.35, in NHW P-value=0.75, meta-analysis P-va...... In NHB P-value=0.35, in NHW P-value=0.75, meta-analysis P-value=0.53. More... We didn't find significant evidence for this specific SNP in...... We didn't find significant evidence for this specific SNP in our study. More... Non-significant
Guffanti, G.,2013 PTSD In the DNHS subjects: B=5.45, P-value=5.10E-08, OR=2.89, 95...... In the DNHS subjects: B=5.45, P-value=5.10E-08, OR=2.89, 95%CI=1.97-4.23.The Bonferroni corrected P-value=0.035. In NHS-II sample: additive genetic model P-value=0.07, genotypic model P-value=0.03, dominant model P-value=0.01. More... The strongest signal was at SNP rs10170218 with a genome-wid...... The strongest signal was at SNP rs10170218 with a genome-wide significant p-value. And they found suggestive evidence of replication in NHSII. More... Significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
LINC01090 long intergenic non-protein coding RNA 1090 2q32.1 2(1/1/0)

SNPs in LD with rs10170218 (count: 4)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 4)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
RP11-707O23.5 No Adipose Subcutaneous cis GTEx