PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Drury, S. S., et al. (2013). "The association of a novel haplotype in the dopamine transporter with preschool age posttraumatic stress disorder." J Child Adolesc Psychopharmacol 23(4): 236-243.
Phenotype PTSD diagnosis, PTSD symptoms, PTSD category B symptom score, PTSD category C symptom score, PTSD category D symptom score
Trauma Various
Study Design Cross-sectional study
Study Type Candidate gene association study
Sample Size 143 samples
SNP/Marker Size 1 SNP,1 Variant
Predominant Ethnicity Black, Caucasian
Population 87 Black, 41 White, 15 other
Gender 86 males, 57 females
Age 2 hapolotypes: mean age=5.39 years, SD=1.21, 1 haplotype: mean age=5.20 years, SD=1.15, 0 haplotype: mean age=5.16 years, SD=1.03

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 5)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
DAT_3'UTR_VNTR-rs27072, nine repeat-C PTSD category D symptom score SLC6A3 R2=0.09, f=3.6, P-value<0.08, in white subgroup: r2=0.15, P-value<0.04, in black subgroup: r2=0.07, P-value<0.06. Haplotype was also significantly associated with Criterion D...... Haplotype was also significantly associated with Criterion D. Haplotype was significantly associated with the number of criterion D symptoms within the white subgroup and approached significance within the black subgroup. More... Significant
DAT_3'UTR_VNTR-rs27072, nine repeat-C PTSD category C symptom score SLC6A3 R2=0.07, f=2.56, P-value<0.05 Haplotype was also significantly associated with Criterion C...... Haplotype was also significantly associated with Criterion C. More... Significant
DAT_3'UTR_VNTR-rs27072, nine repeat-C PTSD symptoms SLC6A3 R2=0.1, f=3.81, P-value<0.06, in white subgroup: r2=0.13, P-value<0.07, in black subgroup: r2=0.09, P-value<0.01. Haplotype was also significantly associated with total PTSD ...... Haplotype was also significantly associated with total PTSD symptoms. PTSD symptoms within the black subgroup and approached significance with the total number of PTSD symptoms within the white subgroup. More... Significant
DAT_3'UTR_VNTR-rs27072, nine repeat-C PTSD diagnosis SLC6A3 X2=10.47, P-value= 0.005 Haplotype status significantly predicted PTSD diagnosis. Haplotype status significantly predicted PTSD diagnosis. Significant
DAT_3'UTR_VNTR-rs27072, nine repeat-C PTSD category B symptom score SLC6A3 No detail information None None Non-significant