PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Drury, S. S.,2013 PMID: 23647133
Citation	Drury, S. S., et al. (2013). "The association of a novel haplotype in the dopamine transporter with preschool age posttraumatic stress disorder." J Child Adolesc Psychopharmacol 23(4): 236-243.
Phenotype	PTSD diagnosis, PTSD symptoms, PTSD category B symptom score, PTSD category C symptom score, PTSD category D symptom score
Trauma	Various
Study Design	Cross-sectional study
Study Type	Candidate gene association study
Sample Size	143 samples
SNP/Marker Size	1 SNP,1 Variant
Predominant Ethnicity	Black, Caucasian
Population	87 Black, 41 White, 15 other
Gender	86 males, 57 females
Age	2 hapolotypes: mean age=5.39 years, SD=1.21, 1 haplotype: mean age=5.20 years, SD=1.15, 0 haplotype: mean age=5.16 years, SD=1.03

Detail Info

Sample Diagnosis	DSM-IV
Related Diagnostic Tools	the Preschool Age Psychiatric Assessment (PAPA). The PAPA interview was performed by trained research assistants who were blind to genotyping information.
Sample Status	Exclusion criteria were: 1) Head trauma with Glasgow Coma Scale score <7 in the emergency room. 2) Mental retardation, autistic disorder, blindness, deafness, and coming from foreign language-speaking families.
Controls Exposed	NA
Replication Size	None
Result Summary	The number of haplotypes (0, 1, or 2) defined by the presence of the nine repeat allele of rs28363170 (VNTR in the 3'UTR)and the C allele of rs27072 (SNP in the 3'UTR)was significantly associated with both the diagnosis ofPTSDand total PTSD symptoms. Specifically, children with one or two copies of the haplotype had significantly more PTSD symptoms and were more likely to be diagnosed with PTSD than were children without this haplotype.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 5)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
DAT_3'UTR_VNTR-rs27072, nine repeat-C	PTSD category D symptom score	SLC6A3	R²=0.09, f=3.6, P-value<0.08, in white subgroup: r²=0.15, P-value<0.04, in black subgroup: r²=0.07, P-value<0.06.	Haplotype was also significantly associated with Criterion D...... Haplotype was also significantly associated with Criterion D. Haplotype was significantly associated with the number of criterion D symptoms within the white subgroup and approached significance within the black subgroup. More...	Significant
DAT_3'UTR_VNTR-rs27072, nine repeat-C	PTSD category C symptom score	SLC6A3	R²=0.07, f=2.56, P-value<0.05	Haplotype was also significantly associated with Criterion C...... Haplotype was also significantly associated with Criterion C. More...	Significant
DAT_3'UTR_VNTR-rs27072, nine repeat-C	PTSD symptoms	SLC6A3	R²=0.1, f=3.81, P-value<0.06, in white subgroup: r²=0.13, P-value<0.07, in black subgroup: r²=0.09, P-value<0.01.	Haplotype was also significantly associated with total PTSD ...... Haplotype was also significantly associated with total PTSD symptoms. PTSD symptoms within the black subgroup and approached significance with the total number of PTSD symptoms within the white subgroup. More...	Significant
DAT_3'UTR_VNTR-rs27072, nine repeat-C	PTSD diagnosis	SLC6A3	X²=10.47, P-value= 0.005	Haplotype status significantly predicted PTSD diagnosis. Haplotype status significantly predicted PTSD diagnosis.	Significant
DAT_3'UTR_VNTR-rs27072, nine repeat-C	PTSD category B symptom score	SLC6A3	No detail information	None None	Non-significant