Study Report
Study Information
Basic Info
| Reference |
Drury, S. S.,2009 PMID: 19960520
|
| Citation |
Drury, S. S., et al. (2009). "The role of the dopamine transporter (DAT) in the development of PTSD in preschool children." J Trauma Stress 22(6): 534-539. |
| Phenotype |
PTSD diagnosis, PTSD symptoms, PTSD category B symptom score, PTSD category C symptom score, PTSD category D symptom score |
| Trauma |
Hurricane Katrina |
| Study Design |
Cross-sectional study |
| Study Type |
Candidate gene association study |
| Sample Size |
88 samples |
| SNP/Marker Size |
1 Variant |
| Predominant Ethnicity |
Black, Caucasian |
| Population |
49 Black, 35 White, 4 other |
| Gender |
52 males, 36 females |
| Age |
Not mentioned |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
the Preschool Age Psychiatric Assessment (PAPA). The PAPA interview was performed by trained research assistants who were blind to genotyping information. |
| Sample Status |
Children could not participate if they had moderate mental retardation, autistic disorder, deafness, blindness, or were non-English speaking. |
| Controls Exposed |
NA |
| Replication Size |
None |
| Result Summary |
A diagnosis according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, total symptoms, and specifically Criterion D symptoms were significantly more likely to be found in children with the 9 allele. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 5)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
DAT_3'UTR_VNTR
|
PTSD symptoms |
SLC6A3 |
Z=2.22, P-value<0.05 |
Individuals with the 9 allele (9/9 or 9/10 genotypes) had si......
Individuals with the 9 allele (9/9 or 9/10 genotypes) had significantly greater total number of PTSD symptoms than homozygous 10 children.
More...
|
Significant |
|
DAT_3'UTR_VNTR
|
PTSD category D symptom score |
SLC6A3 |
Z=2.46, P-value<0.05 |
Children with the 9 allele had significantly more Criterion ......
Children with the 9 allele had significantly more Criterion D symptoms compared to homozygous 10/10 children.
More...
|
Significant |
|
DAT_3'UTR_VNTR
|
PTSD diagnosis |
SLC6A3 |
OR=2.40, 95% CI=1.02-5.67, Wald X2=4.00, P-value< 0.05 |
Logistic regression results revealed that there is a signifi......
Logistic regression results revealed that there is a significant difference in PTSD diagnosis according to genotype classification.
More...
|
Significant |
|
DAT_3'UTR_VNTR
|
PTSD category B symptom score |
SLC6A3 |
Z=1.02, P-value>0.05 |
There was no significant differences with Criterion B sympto......
There was no significant differences with Criterion B symptom counts.
More...
|
Non-significant |
|
DAT_3'UTR_VNTR
|
PTSD category C symptom score |
SLC6A3 |
Z=1.90, P-value>0.05 |
There was no significant differences with Criterion c sympto......
There was no significant differences with Criterion c symptom counts.
More...
|
Non-significant |
