Study Report
Study Information
Basic Info
| Reference |
Chang, S. C.,2012 PMID: 22745713
|
| Citation |
Chang, S. C., et al. (2012). "Molecular variation at the SLC6A3 locus predicts lifetime risk of PTSD in the Detroit Neighborhood Health Study." PLoS One 7(6): e39184. |
| Phenotype |
PTSD diagnosis |
| Trauma |
Various |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
62 cases, 258 controls |
| SNP/Marker Size |
1 Variant |
| Predominant Ethnicity |
Black |
| Population |
African American |
| Gender |
Case: 64.52% females, control: 56.59% females |
| Age |
Case: mean age= 61 years, control: mean age= 52.19 years |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
A modified version of the PTSD Checklist (PCL-C). |
| Sample Status |
Case: 52.23% lifetime depression, control: 16.73% lifetime depression |
| Controls Exposed |
NS |
| Replication Size |
None |
| Result Summary |
After adjusting for age, sex, socio-economic status, race, smoking, number of traumatic events and lifetime depression, 9R allele carriers showed almost twice the risk of PTSD compared to 10R/10R carriers. A significant (P-value=0.008) interaction was observed whereby 9R allele carriers showed an increased risk of lifetime PTSD only in conjunction with high methylation in the SLC6A3 promoter locus, controlling for the same covariates. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
DAT_3'UTR_VNTR
|
PTSD diagnosis |
SLC6A3 |
OR=1.98, 95% CI=1.02-3.86, P-value=0.04 |
After adjusting for age, sex, socio-economic status, race, s......
After adjusting for age, sex, socio-economic status, race, smoking, number of traumatic events and lifetime depression, 9R allele carriers showed almost twice the risk of PTSD compared to 10R/10R carriers.
More...
|
Significant |
