Study Report
Study Information
Basic Info
| Reference |
Segman, R. H.,2002 PMID: 12232785
|
| Citation |
Segman, R. H., et al. (2002). "Association between the dopamine transporter gene and posttraumatic stress disorder." Mol Psychiatry 7(8): 903-907. |
| Phenotype |
PTSD |
| Trauma |
Various |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
102 cases, 104 controls |
| SNP/Marker Size |
1 Variant |
| Predominant Ethnicity |
Caucasian, Black, Mongloid |
| Population |
Ashkenazi, north Africa, Yemen, Iraq, Iran, and other Asian |
| Gender |
Case: 9 males, 11 females, Control: 9 males, 11 females |
| Age |
Case: mean age=39.7 years,SD=11.7, Control: mean age=33.9 years,SD=10.2 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Clinician Administered PTSD Scale (CAPS), Structured Clinical Interview for DSM-IV Mental Disorders (SCID), Both instruments |
| Sample Status |
Subjects were not included in this study if they suffered from head injury, burn injury or serious physical injury. Additionally, subjects with current or lifetime use of alcohol or illicit drugs, those with past or present psychosis, and those suffering from medical or neurological illness that could confound the assessments, were not included. |
| Controls Exposed |
Yes |
| Replication Size |
None |
| Result Summary |
Significant excess of 9 repeat allele was observed among PTSD patients (43% vs 30.5% in TS controls; X2=6.3, df= 1, P-value= 0.012). An excess of 9 repeat homozygous genotype was also observed in PTSD (20.43% in PTSD vs 9.47% in TS controls; X2=6.11, df= 2, P-value= 0.047). These results provide direct evidence for the involvement of SLC6A3 allelic status in the etiology of PTSD. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
DAT_3'UTR_VNTR
|
PTSD diagnosis |
SLC6A3 |
Allele frequency: X2=6.31, P-value=0.012. Genotype distribution: X2=6.1, P-value=0.047. |
Significant excess of 9 repeat allele was observed among PTS......
Significant excess of 9 repeat allele was observed among PTSD patients. An excess of 9 repeat homozygous genotype was also observed in PTSD.
More...
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Significant |
