SNP Report
Basic Info
| Name | rs2134655 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 3:114139354 - 114139354(+) | ||
| Variant Seq | T | ||
| Ancestral Allele | C | ||
| Ref Seq | C | ||
| Minor Allele Frequence | 0.203275 | ||
| Annotation | intron_variant | ||
| Variant Effect | intron_variant(ENST00000460779, ENST00000295881, ENST00000383673, ENST00000467632) | ||
| SIFT Annotation | tolerated | ||
| SIFT Variant Effect | tolerated(ENST00000295881, ENST00000383673, ENST00000467632, ENST00000460779) | ||
| PolyPhen Annotation | benign; probably_damaging | ||
| PolyPhen Variant Effect | benign(ENST00000295881); probably_damaging(ENST00000383673, ENST00000467632, ENST00000460779) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | n/a | ||
| Chromatin State | Enhancers | ||
| No. of Marker's Association Results | 1 (Positive: 1; Negative: 0; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Wolf, E. J.,2014 | PTSD diagnosis | In discovery sample: OR=0.5907, uncorrected P-value= 0.0003...... In discovery sample: OR=0.5907, uncorrected P-value= 0.0003, correct P-value=0.005. In discovery female subsample: OR= 0.59, uncorrected P-value= 0.03, corrected P-value= 0.23. In discovery male subsample: OR= 0.61, uncorrected P-value= 0.010, corrected P-value= 0.10. More... | The SNP showed nominal evidence of association with lifetime...... The SNP showed nominal evidence of association with lifetime PTSD, withstood correction for multiple testing, result was unchanged when we controlled for total trauma exposure. In men showed nominally significant associations with PTSD again, it showed a nominally significant association with PTSD in women, but it did not withstand multiple testing correction, not on the SNP array used in the replication sample. More... | Significant |
SNP related genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| DRD3 | dopamine receptor D3 | 3q13.3 | 2(1/1/0) |
SNPs in LD with rs2134655 (count: 0)
SNP related eQTL (count: 1)