PTSDgene database

SNP Report

Basic Info
Name rs201252087 dbSNP Ensembl
Location 3:114142742 - 114142742(+)
Variant Seq G
Ancestral Allele A
Ref Seq A
Annotation intron_variant
Variant Effect intron_variant(ENST00000467632, ENST00000460779, ENST00000295881, ENST00000383673)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000467632, ENST00000295881, ENST00000383673, ENST00000460779)
PolyPhen Annotation benign
PolyPhen Variant Effect benign(ENST00000467632, ENST00000295881, ENST00000383673, ENST00000460779)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription
No. of Marker's Association Results 1 (Positive: 1; Negative: 0; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Wolf, E. J.,2014 PTSD diagnosis In discovery sample: OR=0.6447, uncorrected P-value= 0.0009...... In discovery sample: OR=0.6447, uncorrected P-value= 0.0009, correct P-value=0.013. In discovery male subsample: OR= 0.60, uncorrected P-value= 0.003, corrected P-value= 0.04. In discovery female subsample: OR= 0.59, uncorrected P-value= 0.03, corrected P-value= 0.23. More... The SNP showed nominal evidence of association with lifetime...... The SNP showed nominal evidence of association with lifetime PTSD, withstood correction for multiple testing, result was unchanged when we controlled for total trauma exposure. In men showed nominally significant associations with PTSD and withstood correction for multiple testing. Not significantly associated with PTSD in women, not on the SNP array used in the replication sample. More... Significant

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
DRD3 dopamine receptor D3 3q13.3 2(1/1/0)

SNPs in LD with rs201252087 (count: 0)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
LRRC37A4P No Adipose Subcutaneous cis GTEx