PTSDgene database

SNP Report

Basic Info
Name rs2251177 dbSNP Ensembl
Location 3:114139503 - 114139503(+)
Variant Seq A,T
Ancestral Allele T
Ref Seq C
Minor Allele Frequence 0.0421326
Annotation synonymous_variant; missense_variant
Variant Effect synonymous_variant(ENST00000295881, ENST00000460779, ENST00000467632, ENST00000383673); missense_variant(ENST00000295881, ENST00000460779, ENST00000467632, ENST00000383673)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000295881, ENST00000460779, ENST00000467632, ENST00000383673)
PolyPhen Annotation benign
PolyPhen Variant Effect benign(ENST00000295881, ENST00000460779, ENST00000467632, ENST00000383673)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Enhancers
No. of Marker's Association Results 1 (Positive: 1; Negative: 0; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Wolf, E. J.,2014 PTSD diagnosis In replication example: OR= 0.6733, uncorrected P-value= 0....... In replication example: OR= 0.6733, uncorrected P-value= 0.06, correct P-value=0.60. controlling for trauma exposure: OR= 0.69, P-value= 0.11. In replication female subsample: OR= 0.86, uncorrected P-value= 0.54, corrected P-value= 0.10. In replication male subsample: OR= 0.32, uncorrected P-value= 0.01, corrected P-value= 0.17. More... Just failed to meet the threshold for a nominal association ...... Just failed to meet the threshold for a nominal association in the replication sample. When controlling for trauma exposure, this association became non-significant in the full sample.In the men, the G allele of rs2251177 showed evidence of a nominally significant association with PTSD. More... Significant

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
DRD3 dopamine receptor D3 3q13.3 2(1/1/0)

SNPs in LD with rs2251177 (count: 0)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
LRRC37A4P No Adipose Subcutaneous cis GTEx