SNP Report
Basic Info
| Name | rs2251177 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 3:114139503 - 114139503(+) | ||
| Variant Seq | A,T | ||
| Ancestral Allele | T | ||
| Ref Seq | C | ||
| Minor Allele Frequence | 0.0421326 | ||
| Annotation | synonymous_variant; missense_variant | ||
| Variant Effect | synonymous_variant(ENST00000295881, ENST00000460779, ENST00000467632, ENST00000383673); missense_variant(ENST00000295881, ENST00000460779, ENST00000467632, ENST00000383673) | ||
| SIFT Annotation | tolerated | ||
| SIFT Variant Effect | tolerated(ENST00000295881, ENST00000460779, ENST00000467632, ENST00000383673) | ||
| PolyPhen Annotation | benign | ||
| PolyPhen Variant Effect | benign(ENST00000295881, ENST00000460779, ENST00000467632, ENST00000383673) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | n/a | ||
| Chromatin State | Enhancers | ||
| No. of Marker's Association Results | 1 (Positive: 1; Negative: 0; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Wolf, E. J.,2014 | PTSD diagnosis | In replication example: OR= 0.6733, uncorrected P-value= 0....... In replication example: OR= 0.6733, uncorrected P-value= 0.06, correct P-value=0.60. controlling for trauma exposure: OR= 0.69, P-value= 0.11. In replication female subsample: OR= 0.86, uncorrected P-value= 0.54, corrected P-value= 0.10. In replication male subsample: OR= 0.32, uncorrected P-value= 0.01, corrected P-value= 0.17. More... | Just failed to meet the threshold for a nominal association ...... Just failed to meet the threshold for a nominal association in the replication sample. When controlling for trauma exposure, this association became non-significant in the full sample.In the men, the G allele of rs2251177 showed evidence of a nominally significant association with PTSD. More... | Significant |
SNP related genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| DRD3 | dopamine receptor D3 | 3q13.3 | 2(1/1/0) |
SNPs in LD with rs2251177 (count: 0)
SNP related eQTL (count: 1)