Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
rs4646996
|
PTSD diagnosis |
DRD3 |
In discovery sample: OR=0.6724, uncorrected P-value= 0.002, correct P-value=0.03 |
The SNP showed nominal evidence of association with lifetime......
The SNP showed nominal evidence of association with lifetime PTSD, withstood correction for multiple testing, result was unchanged when we controlled for total trauma exposure. In men showed nominally significant associations with PTSD again, not on the SNP array used in the replication sample.
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|
Significant |
rs9817063
|
PTSD diagnosis |
DRD3 |
In discovery sample: OR=1.427, uncorrected P-value= 0.007, correct P-value=0.07 |
The SNP showed nominal evidence of association with lifetime......
The SNP showed nominal evidence of association with lifetime PTSD, In men showed nominally significant associations with PTSD again.
More...
|
Significant |
rs9868039
|
PTSD diagnosis |
DRD3 |
In discovery sample: OR=0.6883, uncorrected P-value= 0.004, correct P-value=0.049 |
The SNP showed nominal evidence of association with lifetime......
The SNP showed nominal evidence of association with lifetime PTSD, withstood correction for multiple testing, result was unchanged when we controlled for total trauma exposure. In men showed nominally significant associations with PTSD again, not on the SNP array used in the replication sample.
More...
|
Significant |
rs963468
|
PTSD diagnosis |
DRD3 |
In discovery sample: OR=1.457, uncorrected P-value= 0.005, correct P-value=0.051 |
The SNP showed nominal evidence of association with lifetime......
The SNP showed nominal evidence of association with lifetime PTSD, In men showed nominally significant associations with PTSD again.
More...
|
Significant |
rs2251177
|
PTSD diagnosis |
DRD3 |
In replication example: OR= 0.6733, uncorrected P-value= 0.06, correct P-value=0.60. controlling for trauma exposure: OR= 0.69, P-value= 0.11. In replication female subsample: OR= 0.86, uncorrected P-value= 0.54, corrected P-value= 0.10. In replication male subsample: OR= 0.32, uncorrected P-value= 0.01, corrected P-value= 0.17. |
Just failed to meet the threshold for a nominal association ......
Just failed to meet the threshold for a nominal association in the replication sample. When controlling for trauma exposure, this association became non-significant in the full sample.In the men, the G allele of rs2251177 showed evidence of a nominally significant association with PTSD.
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|
Significant |
rs2134655
|
PTSD diagnosis |
DRD3 |
In discovery sample: OR=0.5907, uncorrected P-value= 0.0003, correct P-value=0.005. In discovery female subsample: OR= 0.59, uncorrected P-value= 0.03, corrected P-value= 0.23. In discovery male subsample: OR= 0.61, uncorrected P-value= 0.010, corrected P-value= 0.10. |
The SNP showed nominal evidence of association with lifetime......
The SNP showed nominal evidence of association with lifetime PTSD, withstood correction for multiple testing, result was unchanged when we controlled for total trauma exposure. In men showed nominally significant associations with PTSD again, it showed a nominally significant association with PTSD in women, but it did not withstand multiple testing correction, not on the SNP array used in the replication sample.
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|
Significant |
rs201252087
|
PTSD diagnosis |
DRD3 |
In discovery sample: OR=0.6447, uncorrected P-value= 0.0009, correct P-value=0.013. In discovery male subsample: OR= 0.60, uncorrected P-value= 0.003, corrected P-value= 0.04. In discovery female subsample: OR= 0.59, uncorrected P-value= 0.03, corrected P-value= 0.23. |
The SNP showed nominal evidence of association with lifetime......
The SNP showed nominal evidence of association with lifetime PTSD, withstood correction for multiple testing, result was unchanged when we controlled for total trauma exposure. In men showed nominally significant associations with PTSD and withstood correction for multiple testing. Not significantly associated with PTSD in women, not on the SNP array used in the replication sample.
More...
|
Significant |