PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Wolf, E. J.,2014 PMID: 25158632
Citation	Wolf, E. J., et al. (2014). "The dopamine D3 receptor gene and posttraumatic stress disorder." J Trauma Stress 27(4): 379-387.
Phenotype	PTSD diagnosis
Trauma	Lifetime traumatic events
Study Design	Case-control
Study Type	Candidate gene association study
Sample Size	296 cases, 195 controls
SNP/Marker Size	26 SNPs
Predominant Ethnicity	Caucasian
Population	White non-Hispanic
Gender	Case: 217 males and 79 females, Control: 102 males and 93 females
Age	Overall: mean age= 51.95 years,SD= 11.06

Detail Info

Sample Diagnosis	DSM-IV
Related Diagnostic Tools	Clinician Administered PTSD Scale (CAPS), Traumatic Life Events Questionnaire (TLEQ), both studies included comprehensive structured diagnostic interviews.
Sample Status	The current study was based on 491 of these individuals who reported lifetime exposure to a traumatic event and had valid lifetime PTSD interview data.
Controls Exposed	Yes
Replication Size	601 trauma-exposed African American
Result Summary	In the discovery sample, four single nucleotide polymorphisms (SNPs), rs2134655, rs201252087, rs4646996, and rs9868039, showed evidence of association with PTSD and withstood correction for multiple testing. The minor alleles were associated with reduced risk for PTSD. In the replication sample, rs2251177, located 149 base pairs away from the most significant SNP in the discovery sample, was nominally associated with PTSD in men (odds ratio: 0.32).In conclusion, the results of this study provide initial evidence that polymorphisms in DRD3, perhaps reflecting a single risk locus, may be associated with lifetime PTSD diagnosis. The relationship between DRD3 and PTSD may also be a reflection of the sensitivity of the dopamine system to stress.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 7)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs4646996	PTSD diagnosis	DRD3	In discovery sample: OR=0.6724, uncorrected P-value= 0.002, correct P-value=0.03	The SNP showed nominal evidence of association with lifetime...... The SNP showed nominal evidence of association with lifetime PTSD, withstood correction for multiple testing, result was unchanged when we controlled for total trauma exposure. In men showed nominally significant associations with PTSD again, not on the SNP array used in the replication sample. More...	Significant
rs9817063	PTSD diagnosis	DRD3	In discovery sample: OR=1.427, uncorrected P-value= 0.007, correct P-value=0.07	The SNP showed nominal evidence of association with lifetime...... The SNP showed nominal evidence of association with lifetime PTSD, In men showed nominally significant associations with PTSD again. More...	Significant
rs9868039	PTSD diagnosis	DRD3	In discovery sample: OR=0.6883, uncorrected P-value= 0.004, correct P-value=0.049	The SNP showed nominal evidence of association with lifetime...... The SNP showed nominal evidence of association with lifetime PTSD, withstood correction for multiple testing, result was unchanged when we controlled for total trauma exposure. In men showed nominally significant associations with PTSD again, not on the SNP array used in the replication sample. More...	Significant
rs963468	PTSD diagnosis	DRD3	In discovery sample: OR=1.457, uncorrected P-value= 0.005, correct P-value=0.051	The SNP showed nominal evidence of association with lifetime...... The SNP showed nominal evidence of association with lifetime PTSD, In men showed nominally significant associations with PTSD again. More...	Significant
rs2251177	PTSD diagnosis	DRD3	In replication example: OR= 0.6733, uncorrected P-value= 0.06, correct P-value=0.60. controlling for trauma exposure: OR= 0.69, P-value= 0.11. In replication female subsample: OR= 0.86, uncorrected P-value= 0.54, corrected P-value= 0.10. In replication male subsample: OR= 0.32, uncorrected P-value= 0.01, corrected P-value= 0.17.	Just failed to meet the threshold for a nominal association ...... Just failed to meet the threshold for a nominal association in the replication sample. When controlling for trauma exposure, this association became non-significant in the full sample.In the men, the G allele of rs2251177 showed evidence of a nominally significant association with PTSD. More...	Significant
rs2134655	PTSD diagnosis	DRD3	In discovery sample: OR=0.5907, uncorrected P-value= 0.0003, correct P-value=0.005. In discovery female subsample: OR= 0.59, uncorrected P-value= 0.03, corrected P-value= 0.23. In discovery male subsample: OR= 0.61, uncorrected P-value= 0.010, corrected P-value= 0.10.	The SNP showed nominal evidence of association with lifetime...... The SNP showed nominal evidence of association with lifetime PTSD, withstood correction for multiple testing, result was unchanged when we controlled for total trauma exposure. In men showed nominally significant associations with PTSD again, it showed a nominally significant association with PTSD in women, but it did not withstand multiple testing correction, not on the SNP array used in the replication sample. More...	Significant
rs201252087	PTSD diagnosis	DRD3	In discovery sample: OR=0.6447, uncorrected P-value= 0.0009, correct P-value=0.013. In discovery male subsample: OR= 0.60, uncorrected P-value= 0.003, corrected P-value= 0.04. In discovery female subsample: OR= 0.59, uncorrected P-value= 0.03, corrected P-value= 0.23.	The SNP showed nominal evidence of association with lifetime...... The SNP showed nominal evidence of association with lifetime PTSD, withstood correction for multiple testing, result was unchanged when we controlled for total trauma exposure. In men showed nominally significant associations with PTSD and withstood correction for multiple testing. Not significantly associated with PTSD in women, not on the SNP array used in the replication sample. More...	Significant