PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Wolf, E. J., et al. (2014). "The dopamine D3 receptor gene and posttraumatic stress disorder." J Trauma Stress 27(4): 379-387.
Phenotype PTSD diagnosis
Trauma Lifetime traumatic events
Study Design Case-control
Study Type Candidate gene association study
Sample Size 296 cases, 195 controls
SNP/Marker Size 26 SNPs
Predominant Ethnicity Caucasian
Population White non-Hispanic
Gender Case: 217 males and 79 females, Control: 102 males and 93 females
Age Overall: mean age= 51.95 years,SD= 11.06

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 7)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
rs4646996 PTSD diagnosis DRD3 In discovery sample: OR=0.6724, uncorrected P-value= 0.002, correct P-value=0.03 The SNP showed nominal evidence of association with lifetime...... The SNP showed nominal evidence of association with lifetime PTSD, withstood correction for multiple testing, result was unchanged when we controlled for total trauma exposure. In men showed nominally significant associations with PTSD again, not on the SNP array used in the replication sample. More... Significant
rs9817063 PTSD diagnosis DRD3 In discovery sample: OR=1.427, uncorrected P-value= 0.007, correct P-value=0.07 The SNP showed nominal evidence of association with lifetime...... The SNP showed nominal evidence of association with lifetime PTSD, In men showed nominally significant associations with PTSD again. More... Significant
rs9868039 PTSD diagnosis DRD3 In discovery sample: OR=0.6883, uncorrected P-value= 0.004, correct P-value=0.049 The SNP showed nominal evidence of association with lifetime...... The SNP showed nominal evidence of association with lifetime PTSD, withstood correction for multiple testing, result was unchanged when we controlled for total trauma exposure. In men showed nominally significant associations with PTSD again, not on the SNP array used in the replication sample. More... Significant
rs963468 PTSD diagnosis DRD3 In discovery sample: OR=1.457, uncorrected P-value= 0.005, correct P-value=0.051 The SNP showed nominal evidence of association with lifetime...... The SNP showed nominal evidence of association with lifetime PTSD, In men showed nominally significant associations with PTSD again. More... Significant
rs2251177 PTSD diagnosis DRD3 In replication example: OR= 0.6733, uncorrected P-value= 0.06, correct P-value=0.60. controlling for trauma exposure: OR= 0.69, P-value= 0.11. In replication female subsample: OR= 0.86, uncorrected P-value= 0.54, corrected P-value= 0.10. In replication male subsample: OR= 0.32, uncorrected P-value= 0.01, corrected P-value= 0.17. Just failed to meet the threshold for a nominal association ...... Just failed to meet the threshold for a nominal association in the replication sample. When controlling for trauma exposure, this association became non-significant in the full sample.In the men, the G allele of rs2251177 showed evidence of a nominally significant association with PTSD. More... Significant
rs2134655 PTSD diagnosis DRD3 In discovery sample: OR=0.5907, uncorrected P-value= 0.0003, correct P-value=0.005. In discovery female subsample: OR= 0.59, uncorrected P-value= 0.03, corrected P-value= 0.23. In discovery male subsample: OR= 0.61, uncorrected P-value= 0.010, corrected P-value= 0.10. The SNP showed nominal evidence of association with lifetime...... The SNP showed nominal evidence of association with lifetime PTSD, withstood correction for multiple testing, result was unchanged when we controlled for total trauma exposure. In men showed nominally significant associations with PTSD again, it showed a nominally significant association with PTSD in women, but it did not withstand multiple testing correction, not on the SNP array used in the replication sample. More... Significant
rs201252087 PTSD diagnosis DRD3 In discovery sample: OR=0.6447, uncorrected P-value= 0.0009, correct P-value=0.013. In discovery male subsample: OR= 0.60, uncorrected P-value= 0.003, corrected P-value= 0.04. In discovery female subsample: OR= 0.59, uncorrected P-value= 0.03, corrected P-value= 0.23. The SNP showed nominal evidence of association with lifetime...... The SNP showed nominal evidence of association with lifetime PTSD, withstood correction for multiple testing, result was unchanged when we controlled for total trauma exposure. In men showed nominally significant associations with PTSD and withstood correction for multiple testing. Not significantly associated with PTSD in women, not on the SNP array used in the replication sample. More... Significant