PTSDgene database

SNP Report

Basic Info
Name rs4646996 dbSNP Ensembl
Location 3:114130718 - 114130718(+)
Variant Seq T
Ancestral Allele C
Ref Seq C
Minor Allele Frequence 0.440495
Annotation intron_variant
Variant Effect intron_variant(ENST00000460779, ENST00000467632, ENST00000383673, ENST00000295881)
SIFT Annotation deleterious; tolerated
SIFT Variant Effect deleterious(ENST00000460779, ENST00000467632, ENST00000383673); tolerated(ENST00000295881)
PolyPhen Annotation benign; probably_damaging
PolyPhen Variant Effect benign(ENST00000295881); probably_damaging(ENST00000460779, ENST00000467632, ENST00000383673)
rSNP? No Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Inactive region
No. of Marker's Association Results 1 (Positive: 1; Negative: 0; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Wolf, E. J.,2014 PTSD diagnosis In discovery sample: OR=0.6724, uncorrected P-value= 0.002,...... In discovery sample: OR=0.6724, uncorrected P-value= 0.002, correct P-value=0.03 More... The SNP showed nominal evidence of association with lifetime...... The SNP showed nominal evidence of association with lifetime PTSD, withstood correction for multiple testing, result was unchanged when we controlled for total trauma exposure. In men showed nominally significant associations with PTSD again, not on the SNP array used in the replication sample. More... Significant

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
DRD3 dopamine receptor D3 3q13.3 2(1/1/0)

SNPs in LD with rs4646996 (count: 4)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 1)

LD-proxies (count: 3)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
LRRC37A4P No Adipose Subcutaneous cis GTEx