SNP Report

Basic Info

Name	rs4646996 dbSNP Ensembl
Location	3:114130718 - 114130718(+)
Variant Seq	T
Ancestral Allele	C
Ref Seq	C
Minor Allele Frequence	0.440495
Annotation	intron_variant
Variant Effect	intron_variant(ENST00000460779, ENST00000467632, ENST00000383673, ENST00000295881)
SIFT Annotation	deleterious; tolerated
SIFT Variant Effect	deleterious(ENST00000460779, ENST00000467632, ENST00000383673); tolerated(ENST00000295881)
PolyPhen Annotation	benign; probably_damaging
PolyPhen Variant Effect	benign(ENST00000295881); probably_damaging(ENST00000460779, ENST00000467632, ENST00000383673)
rSNP?	No Link in rVarBase
Related Regulatory Elements	n/a
Chromatin State	Inactive region
No. of Marker's Association Results	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Wolf, E. J.,2014	PTSD diagnosis	In discovery sample: OR=0.6724, uncorrected P-value= 0.002,...... In discovery sample: OR=0.6724, uncorrected P-value= 0.002, correct P-value=0.03 More...	The SNP showed nominal evidence of association with lifetime...... The SNP showed nominal evidence of association with lifetime PTSD, withstood correction for multiple testing, result was unchanged when we controlled for total trauma exposure. In men showed nominally significant associations with PTSD again, not on the SNP array used in the replication sample. More...	Significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
DRD3	dopamine receptor D3	3q13.3	2(1/1/0)

SNPs in LD with rs4646996 (count: 4)

The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r²<=0.8.


rs_ID	Annotation	No. of Association Results(Positive/Negative/Trend)	r²[population]
rs9817063	downstream_gene_variant(ENST00000467632, ENST00000295881, ENST00000460779, ENST00000383673)	1(1/0/0)	0.8989[EUR]

rs_ID	Literature-origin SNPs with LD	Annotation	r²[population]
rs7632193	rs9817063 rs4646996	intron_variant	0.9086[EUR]
rs2399496	rs9817063 rs4646996	downstream_gene_variant	0.9842[EUR]
rs9845417	rs9817063 rs4646996	intron_variant	0.9086[EUR]

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
LRRC37A4P	No	Adipose Subcutaneous	cis	GTEx