SNP Report
Basic Info
| Name | rs4576167 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 5:168459692 - 168459692(+) | ||
| Variant Seq | C | ||
| Ancestral Allele | G | ||
| Ref Seq | G | ||
| Minor Allele Frequence | 0.256989 | ||
| Annotation | intron_variant; non_coding_transcript_variant | ||
| Variant Effect | intron_variant(ENST00000524038, ENST00000393895, ENST00000265293, ENST00000522140, ENST00000619752, ENST00000524228, ENST00000521089); non_coding_transcript_variant(ENST00000522140) | ||
| SIFT Annotation | tolerated | ||
| SIFT Variant Effect | tolerated(ENST00000524038, ENST00000619752, ENST00000393895, ENST00000524228, ENST00000521089, ENST00000265293) | ||
| PolyPhen Annotation | benign | ||
| PolyPhen Variant Effect | benign(ENST00000524038, ENST00000619752, ENST00000393895, ENST00000524228, ENST00000521089, ENST00000265293) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | Chromatin interactive region | ||
| Chromatin State | Weak transcription;Strong transcription | ||
| No. of Marker's Association Results | 4 (Positive: 4; Negative: 0; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Wilker, S.,2013 | Current PTSD | In Rwandan Sample: did not survive multiple comparison corr...... In Rwandan Sample: did not survive multiple comparison correction, In the Ugandan sample: LR= 4.64, P-value= 0.03, OR= 0.30 [95% CI = 0.10-0.99] More... | In the Ugandan sample, an strong association of the SNP wit...... In the Ugandan sample, an strong association of the SNP with current PTSD was observed. More... | Significant |
| Wilker, S.,2013 | PDS hyperarousal score | In Rwandan Sample: no detail information, In the Ugandan sa...... In Rwandan Sample: no detail information, In the Ugandan sample: Exclusion of one outlier: LR= 5.52, P-value= 0.02 More... | The SNP has a significant association with the PDS hyperarou...... The SNP has a significant association with the PDS hyperarousal score. More... | Significant |
| Wilker, S.,2013 | PDS intrusion score | In Rwandan Sample: no detail information, In the Ugandan sa...... In Rwandan Sample: no detail information, In the Ugandan sample: Exclusion of one outlier: LR= 5.35, P-value= 0.02 More... | The SNP has a significant association with the PDS intrusion...... The SNP has a significant association with the PDS intrusion score. More... | Significant |
| Wilker, S.,2013 | PTSD diagnosis | In Rwandan Sample: nominal association P-value=0.000075 In Rwandan Sample: nominal association P-value=0.000075 | Remain significant after correcting for multiple comparisons...... Remain significant after correcting for multiple comparisons. Minor allele carriers of rs4576167 displayed a reduced risk toward lifetime PTSD development. More... | Significant |
SNP related genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| WWC1 | WW and C2 domain containing 1 | 5q34 | 6(6/0/0) |
| RARS | arginyl-tRNA synthetase | 5q35.1 | rSNP target |
SNPs in LD with rs4576167 (count: 27)
Literature-origin SNPs (count: 1)
LD-proxies (count: 26)
SNP related eQTL (count: 1)