PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Wilker, S., et al. (2013). "The role of memory-related gene WWC1 (KIBRA) in lifetime posttraumatic stress disorder: evidence from two independent samples from African conflict regions." Biol Psychiatry 74(9): 664-671.
Phenotype Current PTSD, PTSD diagnosis, PDS intrusions score, PDS hyperarousal score
Trauma Rwandan genocide, the rebel war in Northern Uganda
Study Design Cross-sectional study
Study Type Candidate gene association study
Sample Size Rwandan Sample: 172 cases and 220 controls, Ugandan Sample: 40 cases and 359 controls
SNP/Marker Size 115 SNPs
Predominant Ethnicity Black
Population Rwanda,Uganda
Gender Rwandan Sample: 198 males and 194 females, Ugandan Sample: 196 males and 213 females
Age Rwandan Sample: mean age=34.62 years, SD=5.89, Ugandan Sample: mean age=32.27 years, SD=11.83

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 8)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
rs4576167 PTSD diagnosis WWC1 In Rwandan Sample: nominal association P-value=0.000075 Remain significant after correcting for multiple comparisons...... Remain significant after correcting for multiple comparisons. Minor allele carriers of rs4576167 displayed a reduced risk toward lifetime PTSD development. More... Significant
rs4576167 PDS intrusion score WWC1 In Rwandan Sample: no detail information, In the Ugandan sample: Exclusion of one outlier: LR= 5.35, P-value= 0.02 The SNP has a significant association with the PDS intrusion...... The SNP has a significant association with the PDS intrusion score. More... Significant
rs10038727 PDS intrusion score WWC1 In Rwandan Sample: did not survive multiple comparison correction, In the Ugandan sample: Exclusion of one outlier: LR= 5.07, P-value= 0.02 The SNP has a significant association with the PDS intrusion...... The SNP has a significant association with the PDS intrusion score. More... Significant
rs10038727 Current PTSD WWC1 In Rwandan Sample: no detail information, In the Ugandan sample: LR= 4.58, P-value= 0.03, OR= 0.31 [95% CI= 0.10-0.99] In the Ugandan sample, an strong association of the SNP wit...... In the Ugandan sample, an strong association of the SNP with current PTSD was observed. More... Significant
rs4576167 Current PTSD WWC1 In Rwandan Sample: did not survive multiple comparison correction, In the Ugandan sample: LR= 4.64, P-value= 0.03, OR= 0.30 [95% CI = 0.10-0.99] In the Ugandan sample, an strong association of the SNP wit...... In the Ugandan sample, an strong association of the SNP with current PTSD was observed. More... Significant
rs10038727 PTSD diagnosis WWC1 In Rwandan Sample: nominal association P-value=0.000075 Remain significant after correcting for multiple comparisons...... Remain significant after correcting for multiple comparisons. Minor allele carriers of rs10038727 displayed a reduced risk toward lifetime PTSD development. More... Significant
rs4576167 PDS hyperarousal score WWC1 In Rwandan Sample: no detail information, In the Ugandan sample: Exclusion of one outlier: LR= 5.52, P-value= 0.02 The SNP has a significant association with the PDS hyperarou...... The SNP has a significant association with the PDS hyperarousal score. More... Significant
rs10038727 PDS hyperarousal score WWC1 In Rwandan Sample: no detail information, In the Ugandan sample: Exclusion of one outlier: LR= 5.24, P-value= 0.02 The SNP has a significant association with the PDS hyperarou...... The SNP has a significant association with the PDS hyperarousal score. More... Significant