Study Report
Study Information
Basic Info
| Reference |
Lee, Heon-Jeong,2006 PMID: 2006-06368-006
|
| Citation |
Lee, H.-J., et al. (2006). "No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and post-traumatic stress disorder." Stress and Health: Journal of the International Society for the Investigation of Stress 22(2): 115-119. |
| Phenotype |
PTSD |
| Trauma |
Clinical populations |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
107 patients, 161 control |
| SNP/Marker Size |
1 SNP |
| Predominant Ethnicity |
Mongloid |
| Population |
Korean |
| Gender |
107 patients: males/females=45/62; 161 control group: males/females = 52/108. |
| Age |
107 patients: mean age=34.06 years, SD=10.25. 161 control group: mean age=32.41 years, SD=9.76. |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Structured Clinical Interview for DSM-IV-Korean version (SCID-K) |
| Sample Status |
The PTSD patients were recruited from existing clinical populations visiting nine collaborating centers. Subjects with a history of alcohol or drug dependence, neurological disorders,or any concomitant major DSM-IV Axis I or Axis II psychiatric disorder were excluded (except depressive disorder). Patients who had suffered from major depression before the traumatic event were also excluded. However,those PTSD patients who developed major depression within 9 months after the trauma were included in the present study. |
| Controls Exposed |
No |
| Replication Size |
None |
| Result Summary |
In this study, therefore, the genotype and allele frequencies of the BDNF gene Val66Met polymorphism were analyzed in 106 PTSD patients and 161 unrelated healthy controls using a case-control design. The genotype and allele frequencies for the BDNF gene polymorphism did not differ between the two groups. These findings suggest that the BDNF polymorphism investigated herein does not play a major role in the susceptibility to PTSD at least in the Korean population. Further studies designed to explore the relationship between genetic variations of BDNF and the incidence of PTSD in a larger population may be warranted. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs6265
|
PTSD |
BDNF |
Genotype frequency: X2=0.43, df=2, P-value=0.81; allele frequency: X2=0.32, df=1, P-value=0.57. |
The BDNF Val66Met polymorphism had no signi?cant difference ......
The BDNF Val66Met polymorphism had no signi?cant difference between PTSD patients and controls in either the genotype or the allele frequency, although power was so limited. When this comparison was conducted separately by gender, there was no signi?cant difference between PTSD and controls.
More...
|
Non-significant |
