Study Report
Study Information
Basic Info
| Reference |
Bruenig, D.,2016 PMID: 27413557
|
| Citation |
Bruenig, D., et al. (2016). "A Case-Control Study and Meta-Analysis Reveal BDNF Val66Met Is a Possible Risk Factor for PTSD." Neural Plast 2016: 6979435. |
| Phenotype |
PTSD severity |
| Trauma |
Vietnam combat |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
151 cases, 106 controls |
| SNP/Marker Size |
1 SNP |
| Predominant Ethnicity |
Caucasian |
| Population |
Australian |
| Gender |
Not mentioned |
| Age |
Case: mean age=68.47 years,SD=4.18, Control: mean age=69.13 years,SD=4.14 |
Detail Info
| Sample Diagnosis |
DSM-5 |
| Related Diagnostic Tools |
Clinician Administered PTSD Scale for DSM 5 (CAPS), Mini International Neuropsychiatric Interview (MINI) |
| Sample Status |
22 with Major depression, 22 with Dysthymia, 32 with Suicide risk, 39 with Agoraphobia, 8 with Social phobia, 27 with Alcohol dependence, 4 with Alcohol abuse, 1 with Substance dependence, 14 with Generalised anxiety disorder |
| Controls Exposed |
Yes |
| Replication Size |
None |
| Result Summary |
The association between rs6265 (Val66Met) of BDNF gene and PTSD was not significant. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs6265
|
CAPS score |
BDNF |
In total sample: P-value=0.346, in the patient cohort: F(2)=0.501; P-value=0.607. |
Te association between rs6265 (Val66Met) of BDNF gene and PT......
Te association between rs6265 (Val66Met) of BDNF gene and PTSD was not significant.
More...
|
Non-significant |
