PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Zhang, H., et al. (2006). "Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence." Am J Med Genet B Neuropsychiatr Genet 141B(4): 387-393.
Phenotype PTSD
Trauma Various
Study Design Case-control
Study Type Candidate gene association study
Sample Size 96 cases, 250 controls
SNP/Marker Size 1 SNP, 2 Variants
Predominant Ethnicity Caucasian
Population European-American
Gender Case: 73 males and 23 females, Control: 103 males and 147 females
Age Case: mean age=43.5 years,SD=7.2, Control: mean age=37.5 years,SD=19.7

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 4)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
BDNF_exon_C270T PTSD BDNF Chi-square test Allele: P-value=0.841, Genotype: P-value=0.836 No evidence of association was found, inclusion of sex and a...... No evidence of association was found, inclusion of sex and age as factors in logistic regression analyses did not modify the absence of an association. More... Non-significant
BDNF_5'region_G712A PTSD BDNF Chi-square test Allele: P-value=0.753, Genotype: P-value=0.745 No evidence of association was found, inclusion of sex and a...... No evidence of association was found, inclusion of sex and age as factors in logistic regression analyses did not modify the absence of an association. More... Non-significant
rs6265 PTSD BDNF Chi-square test Allele: P-value=0.233, Genotype: P-value=0.306 No evidence of association was found, inclusion of sex and a...... No evidence of association was found, inclusion of sex and age as factors in logistic regression analyses did not modify the absence of an association. More... Non-significant
G-712A-C270T-Val66Met, G-C-A,G-C-G,G-T-G,A-C-G,A-T-A,A-T-G Posttraumatic Stress Disorder BDNF P-value= 0.270 Haplotype frequencies between the five case groups and the c...... Haplotype frequencies between the five case groups and the control group revealed no significant differences. More... Non-significant