PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Zhang, H.,2006 PMID: 16649215
Citation	Zhang, H., et al. (2006). "Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence." Am J Med Genet B Neuropsychiatr Genet 141B(4): 387-393.
Phenotype	PTSD
Trauma	Various
Study Design	Case-control
Study Type	Candidate gene association study
Sample Size	96 cases, 250 controls
SNP/Marker Size	1 SNP, 2 Variants
Predominant Ethnicity	Caucasian
Population	European-American
Gender	Case: 73 males and 23 females, Control: 103 males and 147 females
Age	Case: mean age=43.5 years,SD=7.2, Control: mean age=37.5 years,SD=19.7

Detail Info

Sample Diagnosis	DSM-III-R
Related Diagnostic Tools	SCID for DSM-III-R, the Schedule for Affective Disorders and Schizophrenia-Lifetime Version (SADS-L), or the PTSD section extracted from the SADS-L.
Sample Status	Subjects were recruited from the VA Connecticut Healthcare System, West Haven Campus, which is also the location of the Clinical Neuroscience Division of the National Center for PTSD Research.
Controls Exposed	NS
Replication Size	None
Result Summary	No association was found between these three BDNF gene variants and AD, AFDs, PTSD, or schizophrenia. However, there was a nominally higher frequency of the G-712A G-allele and the G/G genotype in subjects with substance dependence than in controls (Allele: X²= 4.080, df= 1, P-value= 0.043; Genotype: X²= 7.225, df= 2, P-value= 0.027). Although after correction for multiple testing, the findings are not considered significant (threshold P-value was set at 0.020 by the program SNPSpD), logistic regression analyses confirmed the modest association between SNP G-712A and substance dependence, when the sex and age of subjects were taken into consideration.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 4)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
BDNF_exon_C270T	PTSD	BDNF	Chi-square test Allele: P-value=0.841, Genotype: P-value=0.836	No evidence of association was found, inclusion of sex and a...... No evidence of association was found, inclusion of sex and age as factors in logistic regression analyses did not modify the absence of an association. More...	Non-significant
BDNF_5'region_G712A	PTSD	BDNF	Chi-square test Allele: P-value=0.753, Genotype: P-value=0.745	No evidence of association was found, inclusion of sex and a...... No evidence of association was found, inclusion of sex and age as factors in logistic regression analyses did not modify the absence of an association. More...	Non-significant
rs6265	PTSD	BDNF	Chi-square test Allele: P-value=0.233, Genotype: P-value=0.306	No evidence of association was found, inclusion of sex and a...... No evidence of association was found, inclusion of sex and age as factors in logistic regression analyses did not modify the absence of an association. More...	Non-significant
G-712A-C270T-Val66Met, G-C-A,G-C-G,G-T-G,A-C-G,A-T-A,A-T-G	Posttraumatic Stress Disorder	BDNF	P-value= 0.270	Haplotype frequencies between the five case groups and the c...... Haplotype frequencies between the five case groups and the control group revealed no significant differences. More...	Non-significant