Meta-analysis Report
Basic Info
| Reference |
Wang, T.,2015 PMID: 25925851
|
| Citation |
Wang, T. (2015). "Does BDNF Val66Met Polymorphism Confer Risk for Posttraumatic Stress Disorder?" Neuropsychobiology 71(3): 149-153. |
| Objective |
Evidence has indicated that BDNF (brain-derived neurotrophic factor) Val66Met genetic variant could be linked to the development of posttraumatic stress disorder (PTSD). However, clinical observations studying the BDNF polymorphism and the risk of PTSD yielded contradictory results. In this meta-analysis we evaluated the association between BDNF Val66Met and PTSD risk. |
| Study Type |
Candidate gene association study |
| Extract Database |
PubMed, Embase and Cochrane library online databases (An attempt to search more databases, PsycINFO,PsycARTICLES,CNKI.net,Scopus,Web of Science,and HuGENet, but no additional studies were added.) |
| Time Range |
2006 to April 2014 |
Detail Info
| Samples |
6 articles were involved in this meta-analysis, 1 was a longitudinal cohort study; the rest were case-control designed. The related studies were conducted in adults among European (Croatia), Asian (South Korea) and American populations (USA and Brazil). In detail, 3 articles involved healthy individuals as controls, and another 2 papers used people who suffered from the same stress as cases but without PTSD symptoms-1 article contained both types of controls and thus were treated separately as 2 studies.A total of 696 cases and 1,726 controls were included within this meta-analysis. Most of the involved studies had a good TQS in the methodological quality assessment (TQS: 6-9). |
| Statistic Method |
Various inherited models were used in this article to estimate overall odds ratios (ORs) with 95% confidence intervals (CIs): allele model, additive model, codominant model, dominant model and recessive model. In the case of significant heterogeneity, a random effects model in the Mantel-Haenszel method was applied for the pooling analysis. Heterogeneity was evaluated by Q test and significant heterogeneity was assigned as I2 statistic. Publication bias and subgroup analyses (in different control status or ethnicity) were further conducted. Sensitive analyses were also performed by the removal of studies deviating from the Hardy-Weinberg equilibrium (HWE) in the control group (X2>3.84). STATA software (version SE 11.0) was used for all the pooled analyses. |
| Basic Result |
They did not found a significant overall effect of BDNF Val66Met on the susceptibility to PTSD under various genetic models. |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs6265
|
PTSD |
BDNF |
Our study did not found a significant overall effect of BDNF Val66Met on the susceptibility to PTSD under various genetic models. |
Their pooled analyses did not demonstrate a significant over......
Their pooled analyses did not demonstrate a significant overall effect of the BDNF Val66Met allele on the development of PTSD within the selected genetic models.
More...
|
Non-significant |
