Study Report
Study Information
Basic Info
| Reference |
Pivac, N.,2012 PMID: 21728904
|
| Citation |
Pivac, N., et al. (2012). "The association between brain-derived neurotrophic factor Val66Met variants and psychotic symptoms in posttraumatic stress disorder." World J Biol Psychiatry 13(4): 306-311. |
| Phenotype |
Psychotic symptoms in PTSD |
| Trauma |
Combat |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
370 cases(76 with and 294 without secondary psychotic features), 206 controls |
| SNP/Marker Size |
1 SNP |
| Predominant Ethnicity |
Caucasian |
| Population |
Croatian |
| Gender |
All males |
| Age |
Mean age= 42.3 years, SD=7.1 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Structured Clinical Interview for DSM-IV (SCID), Positive and Negative Syndrome Scale (PANSS), Clinician Administered PTSD Scale (CAPS), The diagnosis of PTSD was made by a team of psychiatrists. |
| Sample Status |
The exclusion criteria were a history of any psychiatric disorders, comorbid substance abuse, and traumatic experience other than combat-related experience. Patients with comorbid depression (MDD) and anxious depressive disorder, which were secondary to the primary PTSD, were included. |
| Controls Exposed |
Yes |
| Replication Size |
None |
| Result Summary |
Veterans with psychotic PTSD were more frequently carriers of one or two Met alleles of the BDNF Val66Met polymorphism than veterans with PTSD without psychotic features and veterans without PTSD. The study shows that veterans with psychotic PTSD carried more Met alleles of the BDNF Val66Met than non-psychotic veterans with PTSD or veterans without PTSD. The results might add further support to the hypothesis that psychotic PTSD is a more severe subtype of PTSD. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs6265
|
Psychotic symptoms in PTSD |
BDNF |
Case vs. control: genotype: X2= 2.426, P-value= 0.297; allele: X2= 1.625, P-value= 0.202; Met carriers versus the homozygous Val/Val genotype: X2= 1.095, P-value= 0.295. Between mild, moderate and severe PTSD symptoms: genotype: X2= 5.532, P-value= 0.237; allele: X2= 1.00, P-value= 0.605; Met carriers versus the homozygous Val/Val genotype: X2= 1.356, P-value= 0.508. Veterans with PTSD comorbid with MDD and anxious depressive disorder vs. veterans with PTSD without any comorbidities: genotype: X2= 2.889, P-value= 0.236; allele: X2= 2.557, P-value= 0.110; Met carriers versus the homozygous Val/Val genotype: X2= 1.959, P-value= 0.162. Between veterans with PTSD with or without psychotic symptoms and veterans without PTSD: genotype: X2= 10.082, P-value= 0.039; allele: X2= 7.002, P-value= 0.030; Met carriers versus the homozygous Val/Val genotype: X2= 6.023, P-value= 0.049. |
Rs6265 did not differ significantly when all veterans with P......
Rs6265 did not differ significantly when all veterans with PTSD were compared to veterans without PTSD. There were no significant differences in rs6265 between all veterans with PTSD with mild, moderate and severe PTSD symptoms. rs6265 did not differ significantly between all veterans with PTSD comorbid with MDD and anxious depressive disorder compared to veterans with PTSD without any comorbidities. Significant differences were detected in the frequencies of the BDNF Val66Met variants between veterans with PTSD with or without psychotic symptoms and veterans without PTSD.
More...
|
Significant |
