Study Report
Study Information
Basic Info
| Reference |
van den Heuvel, L.,2016 PMID: 26999419
|
| Citation |
van den Heuvel, L., et al. (2016). "Brain-derived neurotrophic factor Val66met polymorphism and plasma levels in road traffic accident survivors." Anxiety Stress Coping 29(6): 616-629. |
| Phenotype |
PTSD diagnosis, CAPS scores |
| Trauma |
Road traffic accident |
| Study Design |
Cross-sectional study |
| Study Type |
Candidate gene association study |
| Sample Size |
10 cases, 95 controls |
| SNP/Marker Size |
1 SNP |
| Predominant Ethnicity |
Black, Caucasian |
| Population |
South African |
| Gender |
67 males, 48 females |
| Age |
Mean age=31 years,SD=10 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Acute Stress Disorder Scale (ASDS), Clinician-Administered PTSD Scale (CAPS), Mini International Neuropsychiatric Interview (MINI) |
| Sample Status |
42.3% with ASD, 18.9% with current MDD, 55.3% with any MINI disorders |
| Controls Exposed |
NA |
| Replication Size |
None |
| Result Summary |
Neither BDNF Val66Met genotype nor plasma BDNF was significantly associated with the presence or severity of ASD or PTSD. |
| Potential Biomarker |
Plasma BDNF may, therefore, be a marker of trauma load. |
Genetic result reported by this study
Normal genetic result reported by this study (count: 2)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs6265
|
PTSD diagnosis |
BDNF |
OR=0.261, P-value=0.276. |
BDNF Val66Met genotype was not significantly associated with......
BDNF Val66Met genotype was not significantly associated with the presence of PTSD.
More...
|
Non-significant |
|
rs6265
|
CAPS score |
BDNF |
U=656, P-value=0.264 |
BDNF Val66Met genotype was not significantly associated with......
BDNF Val66Met genotype was not significantly associated with the severity of PTSD.
More...
|
Non-significant |
