Study Report
Study Information
Basic Info
| Reference |
Bachmann, A. W.,2005 PMID: 15511603
|
| Citation |
Bachmann, A. W., et al. (2005). "Glucocorticoid receptor polymorphisms and post-traumatic stress disorder." Psychoneuroendocrinology 30(3): 297-306. |
| Phenotype |
PTSD diagnosis |
| Trauma |
Combat |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
118 cases, 42 controls |
| SNP/Marker Size |
8 Variants |
| Predominant Ethnicity |
Caucasian |
| Population |
Australian |
| Gender |
Not mentioned |
| Age |
Case: mean age= 55.7 years, SD=4.2, Control: mean age= 61.2 years, SD=7.1 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
The Clinician Administered PTSD Scale (CAPS). |
| Sample Status |
Patients diagnosed with other active psychiatric disorders were excluded from the program. |
| Controls Exposed |
Yes |
| Replication Size |
None |
| Result Summary |
In conclusion, the N363S and Bcl1 GR polymorphisms were not more frequent in PTSD patients than controls and reported population frequencies. Our PTSD group did not display GC hypersensitivity, as measured by the LD-DST and DVVA. In a subset of PTSD patients with the BclI GG genotype, CAPS scores and basal cortisol levels were negatively correlated. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 3)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
GR_exon_R23K
|
PTSD diagnosis |
NR3C1 |
X2=1.04, P-value= 0.31 |
The R23K carrier frequency in PTSD was not significantly dif......
The R23K carrier frequency in PTSD was not significantly different to that in controls.
More...
|
Non-significant |
|
GR_intron 2_Bcl1
|
PTSD diagnosis |
NR3C1 |
X2=1.83, P-value= 0.4 |
The genotype distributions were not significantly different ......
The genotype distributions were not significantly different between the two groups.
More...
|
Non-significant |
|
GR_exon 2_N363S
|
PTSD diagnosis |
NR3C1 |
X2=0.54, P-value= 0.46 |
The N363S carrier frequency in PTSD was not significantly di......
The N363S carrier frequency in PTSD was not significantly different to that in controls
More...
|
Non-significant |
