Study Report
Study Information
Basic Info
| Reference |
Lian, Y.,2014 PMID: 25113244
|
| Citation |
Lian, Y., et al. (2014). "The relationship between glucocorticoid receptor polymorphisms, stressful life events, social support, and post-traumatic stress disorder." BMC Psychiatry 14: 232. |
| Phenotype |
PTSD |
| Trauma |
Various |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study, Gene-environment interaction study |
| Sample Size |
460 patients and 1158 control |
| SNP/Marker Size |
3 SNPs |
| Predominant Ethnicity |
Mongloid |
| Population |
Chinese Han |
| Gender |
PTSD: 253 males, 207 females; Controls: 662 males, 496 females. |
| Age |
PTSD: mean age=37.87 years, SD=9.85; Controls: mean age=34.47 years, SD=10.84. |
Detail Info
| Sample Diagnosis |
DSM-IV, DSM-5 |
| Related Diagnostic Tools |
Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for PTSD. Chinese Traumatic Life Events Questionnaire (TLEQ). Stressful life events were assessed using the life events scale (LES) developed by Yang and Zhang. Social support was measured with the Chinese Social Support Rating Scale (SSRC). |
| Sample Status |
Six hundred forty patients with PTSD were recruited from the Department of Psychiatry, First Hospital of Xinjiang Medical University and Xinjiang Mental Health Center, Xinjiang, China, between January 2011 and October 2012. |
| Controls Exposed |
No |
| Replication Size |
None |
| Result Summary |
Variation in GR at rs41423247 and rs258747, stressful life events, social support, and the number of traumatic events were each separately associated with the risk for PTSD. A gene-environment interaction among the polymorphisms, rs41423247 and rs258747, the number of traumatic events, stressful life events, and social support resulted in an increased risk for PTSD. High-risk individuals (a large number of traumatic events, G allele of rs258747 and rs41423247, high level stressful life events, and low social support) had a 3.26-fold increased risk of developing PTSD compared to low-risk individuals. The association was statistically significant in the sub-groups with and without childhood trauma. Our data support the notion that stressful life events, the number of trauma events, and social support may play a contributing role in the risk for PTSD by interacting with GR gene polymorphisms. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 3)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs258747
|
PTSD |
NR3C1 |
Logistic regression analysis (after adjusting for age): genotype (A/A, G/A, G/G): P-value=0.003; allele (A with G): P-value=0.001. |
We demonstrated that the presence of GG and GA genotypes and......
We demonstrated that the presence of GG and GA genotypes and the G allele (rs258747) significantly reduced the risk of PTSD, while presence of the A allele and AA genotype was a positive factor with respect to disease risk.
More...
|
Significant |
|
rs10482605
|
PTSD |
NR3C1 |
Logistic regression analysis (after adjusting for age): genotype P-value=0.096, allele P-value=0.087. |
The rs10482605 is not associated with PTSD.
The rs10482605 is not associated with PTSD.
|
Non-significant |
|
rs41423247
|
PTSD |
NR3C1 |
Logistic regression analysis (after adjusting for age): genotype (C/C, C/G, G/G): P-value=0.004; allele (C with G): P-value=0.003, OR=1.29, 95%CI=1.09-1.54. |
Subjects with the G allele and CG genotype (rs41423247) had ......
Subjects with the G allele and CG genotype (rs41423247) had an increased likelihood of PTSD compared with those with the C allele and CC genotype.
More...
|
Significant |
