Study Report
Study Information
Basic Info
| Reference |
Hauer, D.,2011 PMID: 21169818
|
| Citation |
Hauer, D., et al. (2011). "Relationship of a common polymorphism of the glucocorticoid receptor gene to traumatic memories and posttraumatic stress disorder in patients after intensive care therapy." Crit Care Med 39(4): 643-650. |
| Phenotype |
PTSD stress symptom scores |
| Trauma |
Cardiac surgery and intensive care unit treatment |
| Study Design |
Cross-sectional study |
| Study Type |
Candidate gene association study |
| Sample Size |
126 samples |
| SNP/Marker Size |
1 Variant |
| Predominant Ethnicity |
Caucasian |
| Population |
Germany |
| Gender |
96 males, 30 females |
| Age |
BclI G allele carriers: mean age=67.1 years, SD=10.8. Heterozygous carriers or noncarriers of the allele: mean age=65.8 years, SD=9.3 |
Detail Info
| Sample Diagnosis |
Not mentioned |
| Related Diagnostic Tools |
All patients completed a standardized and validated questionnaire evaluating different categories of traumatic memory and PTSD symptoms from ICU treatment. The questionnaire consists of two parts: part A evaluates four standardized categories of traumatic memory from the ICU, and part B quanti?es the presence and intensities of 10 PTSD-related symptoms. |
| Sample Status |
Exclusion criteria were combined coronary artery and valve disease, emergency procedures, severe alcohol or drug abuse, major preexisting neurologic disease or psychiatric illness (e.g., major depressive or bipolar disorder, PTSD, somatoform disorder), current useofsteroidsandseverecomorbidities,suchas chronic organ dysfunction (renal, liver, or pulmonale), or cancer. |
| Controls Exposed |
NA |
| Replication Size |
None |
| Result Summary |
Homozygous BclI G allele carriers are at risk for traumatic memories, posttraumatic stress disorder symptoms, and lower health-related quality of life after cardiac surgery and intensive care unit therapy.The BclI single-nucleotide polymorphism may help to identify individuals at need for tailored medical care. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
GR_intron 2_Bcl1
|
PTSD stress symptom scores |
NR3C1 |
1 week post-ICU: P-value=0.02 |
Homozygous BclI G allele carriers are at risk for posttrauma......
Homozygous BclI G allele carriers are at risk for posttraumatic stress disorder symptoms after cardiac surgery and intensive care unit therapy.
More...
|
Significant |
