Gene Report

Basic Info

Approved Symbol	NOS1AP
Symbol Alias	"KIAA0464\|CAPON"
Approved Name	nitric oxide synthase 1 adaptor protein
Previous Name	nitric oxide synthase 1 (neuronal) adaptor protein
Name Alias	C-terminal PDZ domain ligand of neuronal nitric oxide synthase
Location	1q23.3
Position	chr1:162069774-162370475, 1
External Links	HGNC: 16859 Entrez Gene: 9722 Ensembl: ENSG00000198929 UCSC: uc001gbv.2
No. of Association Results	3 (Positive: 3; Negative: 0; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 3)

Reference	Phenotype	Marker	Gene's Category
Bruenig, D.,2017(b)	CAPS score	rs1337062 ; rs10918671 ; rs12074902 ; rs1415259 ; rs10494366 ; rs16857031 ; rs12029454 ; rs4657178 ; rs10458392 ; rs10753789 ; rs10800465 ; rs1572495 ; rs164148 ; rs4657154 ; rs4526593 ; rs4657164 ; rs449908 ; rs16857019 ; rs945708 ; rs10918762 ; rs10918936 ; rs10919025 ; rs12116744 ; rs12027674 ; rs12122048 ; rs7546353 ; rs7528328 ; rs3897374 ; rs6676737 ; rs6683968 ; rs6677052 ; rs6659953 ; rs6677529 ; rs12742393 ; rs10157390 ; rs2819316 ; rs2819322 ; rs9661075 ; rs347300 ; rs347311 ; rs347282 ; rs111479527 ; rs115298183 ; rs17460657 ; rs12725553 ; rs6700867	Significant
Lawford, B. R.,2013	PTSD	rs451275 - rs386231, CA ; rs451275 - rs386231, CG ; rs451275 - rs386231, TA ; rs451275 - rs386231, TG ; rs1415259 ; rs1415263 ; rs1858232 ; rs2341744 ; rs347300 ; rs347313 ; rs386231 ; rs4531275 ; rs4656355 ; rs4657178 ; rs6683968 ; rs6704393 ; rs945706	Significant
Lawford, B. R.,2013	Mississippi scores	rs386231	Significant

Gene functional annotation

Gene related GO terms (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0033017	sarcoplasmic reticulum membrane	cellular component	ISS[19800018]	1
GO:0003062	regulation of heart rate by chemical signal	biological process	IMP[19247217]	1
GO:1903762	positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	biological process	ISS[18337493]	1
GO:0030018	Z disc	cellular component	ISS[19800018]	4
GO:0010628	positive regulation of gene expression	biological process	ISS[18337493]	14
GO:0005515	protein binding	molecular function	IPI[25416956]	169
GO:0042383	sarcolemma	cellular component	ISS[18337493]	7
GO:0098901	regulation of cardiac muscle cell action potential	biological process	ISS[18337493]; TAS[24665357]	1
GO:0010750	positive regulation of nitric oxide mediated signal transduction	biological process	ISS[18337493]	1
GO:0005829	cytosol	cellular component	ISS[24665357]	78
GO:0005739	mitochondrion	cellular component	ISS[19800018]	29
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	biological process	IMP[19247217]; ISS[18337493]	2
GO:0050999	regulation of nitric-oxide synthase activity	biological process	NAS[20431962]	2
GO:1901381	positive regulation of potassium ion transmembrane transport	biological process	ISS[18337493]	3
GO:0031965	nuclear membrane	cellular component	ISS[24665357]	4
GO:0045428	regulation of nitric oxide biosynthetic process	biological process	NAS[20431962]	1
GO:0048471	perinuclear region of cytoplasm	cellular component	ISS[18337493]	14
GO:0051000	positive regulation of nitric-oxide synthase activity	biological process	ISS[18337493]	4
GO:1902261	positive regulation of delayed rectifier potassium channel activity	biological process	ISS[18337493]	1
GO:1990454	L-type voltage-gated calcium channel complex	cellular component	ISS[24665357]	1
GO:0005901	caveola	cellular component	ISS[19800018]	7
GO:1902514	regulation of generation of L-type calcium current	biological process	ISS[18337493]; TAS[24665357]	2
GO:0042981	regulation of apoptotic process	biological process	NAS[20431962]	3
GO:0030315	T-tubule	cellular component	ISS[24665357]	5
GO:0005634	nucleus	cellular component	ISS[24665357]	81
GO:1902937	inward rectifier potassium channel complex	cellular component	ISS[24665357]	1
GO:0050998	nitric-oxide synthase binding	molecular function	ISS[9459447]	3
GO:0045429	positive regulation of nitric oxide biosynthetic process	biological process	ISS[18337493]	5
GO:2000170	positive regulation of peptidyl-cysteine S-nitrosylation	biological process	ISS[24665357]	1
GO:1901841	regulation of high voltage-gated calcium channel activity	biological process	ISS[18337493\|24665357]	1

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 9)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
NOS1AP	LRP2	No	--	--	10827173 , 10827173 , 10827173
NOS1AP	RASD1	No	--	--	11086993 , 11086993 , 11086993 , 11086993 , 11086993
NOS1AP	NOS1	Yes	--	--	9459447 , 9459447 , 9459447 , 9459447 , 9459447
NOS1AP	APP	No	--	--	21832049
NOS1AP	LRP1	No	--	--	10827173 , 10827173 , 10827173
NOS1AP	PTPRN	No	--	--	11043403 , 11043403
NOS1AP	SYN2	No	--	--	11867766
NOS1AP	LRP8	No	--	--	10827173
NOS1AP	SYN1	No	--	--	11867766 , 11867766 , 11867766