Gene Report

Basic Info

Approved Symbol	NOS1
Previous Symbol	NOS
Symbol Alias	nNOS
Approved Name	nitric oxide synthase 1
Previous Name	nitric oxide synthase 1 (neuronal)
Location	12q24.22
Position	chr12:117208142-117452170, -1
External Links	HGNC: 7872 Entrez Gene: 4842 Ensembl: ENSG00000089250 UCSC: uc001twn.2
No. of Association Results	1 (Positive: 1; Negative: 0; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Bruenig, D.,2017(b)	CAPS score	rs9658570 ; rs1353939 ; rs7959232 ; rs816353 ; rs2291908 ; rs11068428 ; rs3825102 ; rs10744891 ; rs532967 ; rs11068445 ; rs7295972 ; rs549098 ; rs2077171 ; rs474523 ; rs482555 ; rs61938733	Significant

Gene functional annotation

Gene related GO terms (count: 96)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0045471	response to ethanol	biological process	IEA	18
GO:0034618	arginine binding	molecular function	TAS[17029414]	2
GO:0051481	negative regulation of cytosolic calcium ion concentration	biological process	IEA	2
GO:0014069	postsynaptic density	cellular component	IEA	11
GO:0071731	response to nitric oxide	biological process	IEA	1
GO:1902307	positive regulation of sodium ion transmembrane transport	biological process	ISS	1
GO:0045454	cell redox homeostasis	biological process	TAS	2
GO:0031284	positive regulation of guanylate cyclase activity	biological process	IBA	1
GO:0030315	T-tubule	cellular component	IEA	5
GO:0043627	response to estrogen	biological process	IEA	5
GO:0051930	regulation of sensory perception of pain	biological process	IEA	5
GO:0050767	regulation of neurogenesis	biological process	IEA	1
GO:0042582	azurophil granule	cellular component	IEA	1
GO:0005515	protein binding	molecular function	IPI[11149895\|17161399]	169
GO:0007520	myoblast fusion	biological process	TAS[7545544]	3
GO:0019899	enzyme binding	molecular function	IEA	13
GO:0010523	negative regulation of calcium ion transport into cytosol	biological process	TAS[17568574]	1
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	ISS	25
GO:0001917	photoreceptor inner segment	cellular component	ISS[17027776]	2
GO:0007263	nitric oxide mediated signal transduction	biological process	IBA	2
GO:0030018	Z disc	cellular component	IEA	4
GO:1901216	positive regulation of neuron death	biological process	IEA	2
GO:0045906	negative regulation of vasoconstriction	biological process	IEA	1
GO:0045909	positive regulation of vasodilation	biological process	IDA[18048451]; IMP[18391107]	5
GO:0045776	negative regulation of blood pressure	biological process	IBA	5
GO:0005901	caveola	cellular component	IEA	7
GO:0098735	positive regulation of the force of heart contraction	biological process	ISS	1
GO:0097110	scaffold protein binding	molecular function	ISS	2
GO:1902514	regulation of generation of L-type calcium current	biological process	TAS[21536106]	2
GO:0043234	protein complex	cellular component	ISS	10
GO:0033197	response to vitamin E	biological process	IEA	2
GO:0050661	NADP binding	molecular function	ISS	2
GO:1901206	positive regulation of adrenergic receptor signaling pathway involved in heart process	biological process	IEA	1
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	biological process	TAS[21536106]	1
GO:1990425	ryanodine receptor complex	cellular component	TAS[21536106]	1
GO:0051612	negative regulation of serotonin uptake	biological process	ISS	1
GO:0071363	cellular response to growth factor stimulus	biological process	ISS	3
GO:0055114	oxidation-reduction process	biological process	IEA	18
GO:0042136	neurotransmitter biosynthetic process	biological process	TAS[7545544]	5
GO:0045893	positive regulation of transcription, DNA-templated	biological process	ISS	11
GO:1903779	regulation of cardiac conduction	biological process	TAS	1
GO:0001666	response to hypoxia	biological process	IEP[16276418]	13
GO:0048148	behavioral response to cocaine	biological process	IEA	5
GO:0002028	regulation of sodium ion transport	biological process	ISS	2
GO:0016529	sarcoplasmic reticulum	cellular component	IDA[9892689]	1
GO:0005741	mitochondrial outer membrane	cellular component	IEA	4
GO:0012506	vesicle membrane	cellular component	IEA	3
GO:0071260	cellular response to mechanical stimulus	biological process	IEA	2
GO:0042383	sarcolemma	cellular component	IDA[7545544]	7
GO:0006809	nitric oxide biosynthetic process	biological process	ISS[7545544]	2
GO:0031965	nuclear membrane	cellular component	IEA	4
GO:0006527	arginine catabolic process	biological process	IC[7545544]	2
GO:0008285	negative regulation of cell proliferation	biological process	IEA	13
GO:1901205	negative regulation of adrenergic receptor signaling pathway involved in heart process	biological process	TAS[21536106]	1
GO:0042803	protein homodimerization activity	molecular function	IEA	18
GO:0005829	cytosol	cellular component	TAS	78
GO:0007565	female pregnancy	biological process	IEA	9
GO:0035066	positive regulation of histone acetylation	biological process	ISS	3
GO:0033555	multicellular organismal response to stress	biological process	IMP[18391107]	2
GO:1900273	positive regulation of long-term synaptic potentiation	biological process	IEA	2
GO:0044325	ion channel binding	molecular function	ISS; TAS[21536106]	5
GO:0018119	peptidyl-cysteine S-nitrosylation	biological process	ISS	1
GO:0061337	cardiac conduction	biological process	TAS	2
GO:0020037	heme binding	molecular function	ISS	3
GO:0006941	striated muscle contraction	biological process	ISS	1
GO:0034617	tetrahydrobiopterin binding	molecular function	NAS[7488039]	2
GO:0055117	regulation of cardiac muscle contraction	biological process	TAS[9892689]	2
GO:0045202	synapse	cellular component	ISS	7
GO:0004517	nitric-oxide synthase activity	molecular function	IDA[1689048]; ISS[7545544]	1
GO:0046676	negative regulation of insulin secretion	biological process	IEA	2
GO:0043267	negative regulation of potassium ion transport	biological process	ISS	4
GO:0005506	iron ion binding	molecular function	IEA	5
GO:0005737	cytoplasm	cellular component	TAS[17892502]	109
GO:0046870	cadmium ion binding	molecular function	ISS	1
GO:0048471	perinuclear region of cytoplasm	cellular component	ISS[17027776]	14
GO:0032496	response to lipopolysaccharide	biological process	IEA	9
GO:0042738	exogenous drug catabolic process	biological process	ISS	1
GO:0050660	flavin adenine dinucleotide binding	molecular function	ISS	5
GO:0009408	response to heat	biological process	IDA[18048451]	3
GO:0014823	response to activity	biological process	IEA	5
GO:0005516	calmodulin binding	molecular function	IEA	4
GO:0051346	negative regulation of hydrolase activity	biological process	ISS	1
GO:0051926	negative regulation of calcium ion transport	biological process	ISS	2
GO:0010181	FMN binding	molecular function	ISS	1
GO:0045121	membrane raft	cellular component	ISS	7
GO:0007596	blood coagulation	biological process	TAS	11
GO:0017080	sodium channel regulator activity	molecular function	ISS	2
GO:0035094	response to nicotine	biological process	IEA	11
GO:0043434	response to peptide hormone	biological process	IEA	6
GO:0010288	response to lead ion	biological process	IEA	2
GO:0043197	dendritic spine	cellular component	IEA	9
GO:0005856	cytoskeleton	cellular component	ISS[7545544]	12
GO:0043066	negative regulation of apoptotic process	biological process	IEA	9
GO:0007568	aging	biological process	IEA	11
GO:0045822	negative regulation of heart contraction	biological process	IEA	1
GO:0005739	mitochondrion	cellular component	ISS	29

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in PTSDgene
hsa05222	Small cell lung cancer	5
hsa04020	Calcium signaling pathway	11
hsa04730	Long-term depression	4
hsa00330	Arginine and proline metabolism	3

Gene related interactors from protein-protein interactions data in PINA v2 (count: 22)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
NOS1	HDAC1	No	--	--	22318606
NOS1	BDKRB2	No	--	--	10681501 , 10681501 , 10681501
NOS1	ADRA1B	No	--	--	12184796
NOS1	HSPA4	No	--	--	15466472
NOS1	CTBP1	No	--	--	11590170
NOS1	CAMK2A	No	--	--	10400690
NOS1	DLG4	No	--	association	8625413 , 8625413 , 8625413 , 9459447 , 8625413 , 8625413
NOS1	DLG2	No	--	--	8625413 , 8625413
NOS1	NOSIP	No	--	--	15548660
NOS1	ZDHHC23	No	--	--	15105416 , 15105416 , 15105416
NOS1	CAMK4	No	--	--	10400690
NOS1	CAMK1	No	--	--	10400690
NOS1	DYNLL1	No	--	--	8864115
NOS1	PTPRN	No	--	--	11043403
NOS1	CAV3	Yes	--	--	9353265
NOS1	VAC14	No	--	--	17161399 , 17161399 , 17161399 , 17161399 , 17161399 , 17161399 , 17161399 , 17161399 , 17161399 , 17161399 , 17161399 , 17161399 , 17161399 , 17161399 , 17161399 , 17161399 , 17161399 , 17161399 , 17161399
NOS1	DLGAP2	No	--	--	10824095
NOS1	SUMO1	No	--	--	21545853 , 21545853
NOS1	SNTA1	No	--	--	9412493 , 11747091
NOS1	RASD1	No	--	--	11086993 , 11086993
NOS1	STUB1	No	--	--	20729196 , 15466472 , 15466472 , 23109339
NOS1	ADRA1A	No	--	--	12184796