PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Lawford, B. R.,2013 PMID: 23146198
Citation	Lawford, B. R., et al. (2013). "NOS1AP is associated with increased severity of PTSD and depression in untreated combat veterans." J Affect Disord 147(1-3): 87-93.
Phenotype	PTSD, Mississippi scores
Trauma	Combat
Study Design	Case-control
Study Type	Candidate gene association study
Sample Size	121 PTSD and 237 healthy controls
SNP/Marker Size	13 SNPs
Predominant Ethnicity	Caucasian
Population	Australian
Gender	Cases: all male. Controls:139 male and 98 female .
Age	PTSD: mean age=52 years, SD=6.2. Controls: mean age=36.8 years, SD=12.8.

Detail Info

Sample Diagnosis	DSM-IV
Related Diagnostic Tools	PTSD was diagnosed by a consultant psychiatrist or a senior psychiatric registrar. The Mississippi Scale, Beck Depression Inventory: second edition (BDI-II).
Sample Status	All subjects were Vietnam combat veterans who had served in the Australian Armed Forces. PTSD caseness was con?rmed by every patient exceeding the clinical cut-off score of 94 on the Mississippi Scale for Combat-Related PTSD. Patients were also administered the Beck Depression Inventory: second edition (BDI-II).
Controls Exposed	NS
Replication Size	None
Result Summary	The G allele of NOS1AP SNP rs386231 was significantly associated with PTSD (P-value=0.002). Analysis of variance revealed significant differences in BDI-II and Mississippi scores between genotypes for rs386231 with the GG genotype associated with increased severity of depression (P-value=0.002 F=6.839) and higher Mississippi Scale for Combat-Related PTSD scores (P-value=0.033). Haplotype analysis revealed that the C/G haplotype (rs451275/rs386231) was significantly associated with PTSD (P-value=0.001). This is the first study reporting that a variant of the NOS1AP gene is associated with PTSD. Our data also suggest that a genetic variant in NOS1AP may increase the susceptibility to severe depression in patients with PTSD and increased risk for suicide.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 18)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs347300	PTSD	NOS1AP	Allele frequencies: X²=0.409, P-value=0.523, OR=1.11, 95%CI(0.79-1.55).	No significant signals was observed about this SNP. No significant signals was observed about this SNP.	Non-significant
rs347313	PTSD	NOS1AP	Allele frequencies: X²=0.688, P-value=0.407, OR=1.15, 95%CI(0.63-1.22).	No significant signals was observed about this SNP. No significant signals was observed about this SNP.	Non-significant
rs2341744	PTSD	NOS1AP	Allele frequencies: X²=0.976, P-value=0.323, OR=1.20, 95%CI(0.57-1.21).	No significant signals was observed about this SNP. No significant signals was observed about this SNP.	Non-significant
rs451275 - rs386231, TG	PTSD	NOS1AP	The T/G haplotype: P-value=0.844.	No significant signals was observed about this haplotype. No significant signals was observed about this haplotype.	Non-significant
rs451275 - rs386231, TA	PTSD	NOS1AP	The T/A haplotype: P-value=0.086.	No significant signals was observed about this haplotype. No significant signals was observed about this haplotype.	Non-significant
rs451275 - rs386231, CG	PTSD	NOS1AP	The C/G haplotype: P-value=0.001.	Haplotype analysis revealed that the C/G haplotype (rs451275...... Haplotype analysis revealed that the C/G haplotype (rs451275/rs386231) was significantly associated with PTSD. More...	Significant
rs451275 - rs386231, CA	PTSD	NOS1AP	The C/A haplotype: P-value=0.244.	No significant signals was observed about this haplotype. No significant signals was observed about this haplotype.	Non-significant
rs386231	Mississippi scores	NOS1AP	Mississippi scale between rs386231 genotypes, P-value=0.031 between all genotypes (F=3.63). Using multiple comparisons: GG vs. GA Tukey P-value=0.046, Bonferroni P-value=0.053; GG vs. AA Tukey P-value=0.033,Bonferroni P-value=0.037.	Analysis of variance revealed significant differences in Mis...... Analysis of variance revealed significant differences in Mississippi scores between genotypes for rs386231 with the GG genotype associated with higher Mississippi Scale for Combat-Related PTSD scores. More...	Significant
rs4531275	PTSD	NOS1AP	Allele frequencies: X²=1.759, P-value=0.185, OR=1.28, 95%CI(0.53-1.14).	No significant signals was observed about this SNP. No significant signals was observed about this SNP.	Non-significant
rs6704393	PTSD	NOS1AP	Allele frequencies: X²=0.299, P-value=0.585, OR=1.10, 95%CI(0.78-1.54).	No significant signals was observed about this SNP. No significant signals was observed about this SNP.	Non-significant
rs4656355	PTSD	NOS1AP	Allele frequencies: X²=0.158, P-value=0.691, OR=1.07, 95%CI(0.66-1.32).	No significant signals was observed about this SNP. No significant signals was observed about this SNP.	Non-significant
rs6683968	PTSD	NOS1AP	Allele frequencies: X²=0.652, P-value=0.419, OR=1.16, 95%CI(0.59-1.25).	No significant signals was observed about this SNP. No significant signals was observed about this SNP.	Non-significant
rs1858232	PTSD	NOS1AP	Allele frequencies: X²=1.078, P-value=0.299, OR=1.18, 95%CI(0.61-1.18).	No significant signals was observed about this SNP. No significant signals was observed about this SNP.	Non-significant
rs386231	PTSD	NOS1AP	Allele frequencies: X²=9.196, P-value=0.002, OR=1.69, 95%CI(1.18-2.40). Using male only controls: P-value=0.018.	The rs386231 SNP was found to be signi?cantly associated wit...... The rs386231 SNP was found to be signi?cantly associated with PTSD at the allele level. It remained significant when using male only controls for analysis. And it was remained significant at the genotype level. More...	Significant
rs945706	PTSD	NOS1AP	Allele frequencies: X²=0.052, P-value=0.819, OR=1.04, 95%CI(0.73-1.48).	No significant signals was observed about this SNP. No significant signals was observed about this SNP.	Non-significant
rs4657178	PTSD	NOS1AP	Allele frequencies: X²=0.125, P-value=0.724, OR=1.07, 95%CI(0.62-1.39).	No significant signals was observed about this SNP. No significant signals was observed about this SNP.	Non-significant
rs1415263	PTSD	NOS1AP	Allele frequencies: X²=0.000, P-value=0.998, OR=1.00, 95%CI(0.70-1.41).	No significant signals was observed about this SNP. No significant signals was observed about this SNP.	Non-significant
rs1415259	PTSD	NOS1AP	Allele frequencies: X²=0.194, P-value=0.659, OR=1.08, 95%CI(0.65-1.31).	No significant signals was observed about this SNP. No significant signals was observed about this SNP.	Non-significant