Study Report
Study Information
Basic Info
| Reference |
Mustapic, M.,2007 PMID: 17853400
|
| Citation |
Mustapic, M., et al. (2007). "Dopamine beta-hydroxylase (DBH) activity and -1021C/T polymorphism of DBH gene in combat-related post-traumatic stress disorder." Am J Med Genet B Neuropsychiatr Genet 144B(8): 1087-1089. |
| Phenotype |
Chronic PTSD |
| Trauma |
Combat |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
133 PTSD and 34 controls |
| SNP/Marker Size |
1 SNP |
| Predominant Ethnicity |
Caucasian |
| Population |
Croatian |
| Gender |
No more detail information. |
| Age |
Cases:mean age=40.3 years, SD=7.2. Controls: mean age=38.12 years, SD=4.2. |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Structured Clinical Interview (SCID), Clinician-Administered PTSD Scale (CAPS) |
| Sample Status |
Participants were recruited from December 2002 to January 2005 from the Referral Centre for the Stress Related Disorders, Regional Centre for Psychotrauma, Department of Psychiatry, University Hospital Dubrava. Combat veterans with total Hamilton Rating Scale for Depression scores less than 18. |
| Controls Exposed |
Yes |
| Replication Size |
None |
| Result Summary |
Similar frequencies in genotype or allele distribution were found between veterans with or without PTSD. War veterans with PTSD had lower DBH activity, associated with the DBH-1021C/T variant in DBH genes, than veterans without PTSD. A significantly lower plasma DBH activity was found in combat veterans with PTSD carrying the CC genotype as compared to veterans without PTSD carrying the corresponding genotype. Since both groups were exposed to the same trauma, it is possible that a pre-existing trait difference in regulation of NE function contributed to a differential vulnerability to develop PTSD, or that the regulation of DBH expression was different in response to trauma. The results suggest that that genotype-controlled measurement of plasma DBH activity might be used as a potential biological marker of the response to trauma, and that further studies of DBH and other loci related to DA and NA in PTSD are warranted. |
| Potential Biomarker |
The results suggest that that genotype-controlled measurement of plasma DBH activity might be used as a potential biological marker of the response to trauma. |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs1611115
|
Chronic PTSD |
DBH |
Genotype frequencies: X2=2.30; df=2; P-value=0.32; allele frequencies: X2=2.01; df=1; P-value=0.156. |
rs1611115, DBH genotype and allele frequencies were similarl......
rs1611115, DBH genotype and allele frequencies were similarly distributed between the two groups of war veterans.
More...
|
Non-significant |
