Gene Report

Basic Info

Approved Symbol	CAT
Approved Name	catalase
Location	11p13
Position	chr11:34438925-34472062, 1
External Links	HGNC: 1516 Entrez Gene: 847 Ensembl: ENSG00000121691 UCSC: uc001mvm.3
No. of Association Results	1 (Positive: 1; Negative: 0; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy, rSNP target

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Duan, Z. X.,2014	PTSD diagnosis	rs208679 - rs10836233 - rs2300182 - rs769217 - rs7104301 - rs7949972, AAACAC ; rs208679 - rs10836233 - rs2300182 - rs769217 - rs7104301 - rs7949972, AATCAC ; rs208679 - rs10836233 - rs2300182 - rs769217 - rs7104301 - rs7949972 ,AGTCAC ; rs208679 - rs10836233 - rs2300182 - rs769217 - rs7104301 - rs7949972, AGTTAT ; rs208679 - rs10836233 - rs2300182 - rs769217 - rs7104301 - rs7949972, GGTTGT ; rs10836233 ; rs208679 ; rs2300182 ; rs7104301 ; rs769217 ; rs7949972	Significant

Gene functional annotation

Gene related GO terms (count: 66)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0005102	receptor binding	molecular function	IPI[20178365\|21976670]	13
GO:0006641	triglyceride metabolic process	biological process	IEA	6
GO:0051781	positive regulation of cell division	biological process	IEA	1
GO:0014854	response to inactivity	biological process	IEA	2
GO:0004096	catalase activity	molecular function	IDA[16644728\|18312938\|18379038]; TAS	1
GO:0032088	negative regulation of NF-kappaB transcription factor activity	biological process	IEA	3
GO:0043066	negative regulation of apoptotic process	biological process	IMP[16644728]	9
GO:0033197	response to vitamin E	biological process	IEA	2
GO:0007568	aging	biological process	IEA	11
GO:0046872	metal ion binding	molecular function	IEA	20
GO:0033591	response to L-ascorbic acid	biological process	IEA	2
GO:0005829	cytosol	cellular component	IEA	78
GO:0005615	extracellular space	cellular component	IEA	27
GO:0080184	response to phenylpropanoid	biological process	IEA	1
GO:0050661	NADP binding	molecular function	IDA[10656833]	2
GO:0016020	membrane	cellular component	IDA[16210410\|19946888]	42
GO:0020037	heme binding	molecular function	IDA[10656833\|11134921]	3
GO:0042542	response to hydrogen peroxide	biological process	IBA	3
GO:0005783	endoplasmic reticulum	cellular component	IEA	20
GO:0045471	response to ethanol	biological process	IEA	18
GO:0042803	protein homodimerization activity	molecular function	IDA[10656833]	18
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA	9
GO:0098869	cellular oxidant detoxification	biological process	IDA[10514471\|16644728\|18312938\|18379038]; IEA; TAS	3
GO:0009650	UV protection	biological process	IMP[16644728\|17053817]	2
GO:0005782	peroxisomal matrix	cellular component	TAS	1
GO:0009642	response to light intensity	biological process	IEA	2
GO:0006144	purine nucleobase metabolic process	biological process	TAS	3
GO:0042744	hydrogen peroxide catabolic process	biological process	IDA[18379038]	1
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	biological process	IEA	1
GO:0044281	small molecule metabolic process	biological process	TAS	38
GO:0019899	enzyme binding	molecular function	IPI[16781659]	13
GO:0051092	positive regulation of NF-kappaB transcription factor activity	biological process	IEA	8
GO:0070542	response to fatty acid	biological process	IEA	2
GO:0005764	lysosome	cellular component	IEA	4
GO:0001657	ureteric bud development	biological process	IEA	2
GO:0010193	response to ozone	biological process	IEA	2
GO:0005758	mitochondrial intermembrane space	cellular component	IEA	3
GO:0008203	cholesterol metabolic process	biological process	IEA	7
GO:0005925	focal adhesion	cellular component	IDA[21423176]	11
GO:0005794	Golgi apparatus	cellular component	IEA	17
GO:0016209	antioxidant activity	molecular function	IDA[10514471]	2
GO:0032355	response to estradiol	biological process	IEA	9
GO:0055086	nucleobase-containing small molecule metabolic process	biological process	TAS	2
GO:0010288	response to lead ion	biological process	IEA	2
GO:0009060	aerobic respiration	biological process	IEA	4
GO:0020027	hemoglobin metabolic process	biological process	IEA	1
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	molecular function	ISS	1
GO:0005886	plasma membrane	cellular component	IEA	99
GO:0070062	extracellular exosome	cellular component	IDA[23376485\|23533145]	58
GO:0033189	response to vitamin A	biological process	IEA	2
GO:0004046	aminoacylase activity	molecular function	IEA	1
GO:0032868	response to insulin	biological process	IEA	2
GO:0051262	protein tetramerization	biological process	IDA[10656833\|11134921]	6
GO:0051289	protein homotetramerization	biological process	IDA[21976670]	4
GO:0046686	response to cadmium ion	biological process	IEA	2
GO:0005778	peroxisomal membrane	cellular component	ISS	1
GO:0001666	response to hypoxia	biological process	IEA	13
GO:0000302	response to reactive oxygen species	biological process	IMP[16644728]; TAS	3
GO:0006195	purine nucleotide catabolic process	biological process	TAS	1
GO:0005739	mitochondrion	cellular component	IBA	29
GO:0071363	cellular response to growth factor stimulus	biological process	IEA	3
GO:0001649	osteoblast differentiation	biological process	IDA[16210410]	3
GO:0005777	peroxisome	cellular component	IDA[2895531\|9053548\|18379038\|19479899]	3
GO:0014823	response to activity	biological process	IEA	5
GO:0055093	response to hyperoxia	biological process	IEA	2
GO:0042493	response to drug	biological process	IEA	25

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in PTSDgene
hsa05030	Amyotrophic lateral sclerosis (ALS)	3
hsa00380	Tryptophan metabolism	6
hsa00680	Methane metabolism	1

Gene related interactors from protein-protein interactions data in PINA v2 (count: 16)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
CAT	EHHADH	No	--	--	16781659 , 16781659 , 16781659 , 16781659
CAT	USP53	No	--	--	19615732 , 19615732
CAT	HSD17B4	No	biochemical	colocalization	22939629
CAT	KEAP1	No	--	--	21988832 , 21988832
CAT	PTPN11	No	--	--	15556604 , 15556604 , 15556604 , 15556604 , 15556604 , 15556604 , 15556604 , 15556604 , 15556604 , 15556604
CAT	RAB6A	No	--	colocalization	23333653 , 23333653
CAT	TLR10	No	--	--	16482509
CAT	TYSND1	No	--	colocalization	22002062
CAT	ABL2	No	--	--	12777400 , 12777400 , 12777400 , 12777400 , 12777400
CAT	RAB14	No	--	colocalization	23333653 , 23333653
CAT	APP	No	--	--	10567208 , 21832049
CAT	PEX5	No	--	--	10567403 , 20178365 , 22002062
CAT	MECP2	No	biochemical	colocalization	22939629
CAT	UBC	No	--	--	21139048 , 21890473 , 21906983 , 18781797
CAT	STIM1	No	biochemical	colocalization	22939629
CAT	SUMO4	No	--	--	16236267 , 16236267