SNP Report
Basic Info
| Name | rs324420 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 1:46405089 - 46405089(+) | ||
| Variant Seq | A | ||
| Ancestral Allele | C | ||
| Ref Seq | C | ||
| Minor Allele Frequence | 0.261581 | ||
| Annotation | missense_variant; non_coding_transcript_exon_variant; upstream_gene_variant; non_coding_transcript_variant | ||
| Variant Effect | missense_variant(ENST00000243167); non_coding_transcript_exon_variant(ENST00000493735, ENST00000468718); upstream_gene_variant(ENST00000484697, ENST00000493636, ENST00000489366); non_coding_transcript_variant(ENST00000493735, ENST00000468718) | ||
| SIFT Annotation | tolerated | ||
| SIFT Variant Effect | tolerated(ENST00000243167) | ||
| PolyPhen Annotation | probably_damaging | ||
| PolyPhen Variant Effect | probably_damaging(ENST00000243167) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | TF binding region | ||
| Chromatin State | Weak transcription;Enhancers;Strong transcription;Genic enhancers | ||
| No. of Marker's Association Results | 5 (Positive: 1; Negative: 4; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Spagnolo, P. A.,2016 | PTSD symptoms | F(1, 42)=1.18, P-value=0.29 F(1, 42)=1.18, P-value=0.29 | There was no main effect of genotype to PTSD total symptom. There was no main effect of genotype to PTSD total symptom. | Non-significant |
| Spagnolo, P. A.,2016 | PTSD hyperarousal symptoms | F(1, 47)=6.04, P-value=0.02 F(1, 47)=6.04, P-value=0.02 | There was a main effect of genotype on hyperarousal, such th...... There was a main effect of genotype on hyperarousal, such that subjects carrying the low-expressing C385A variant exhibited decreased arousal compared to C homozygotes. More... | Significant |
| Spagnolo, P. A.,2016 | PTSD re-experiencing symptoms | F(1, 52)=0.06, P-value=0.80 F(1, 52)=0.06, P-value=0.80 | There was no main effect of genotype to PTSD re-experiencing...... There was no main effect of genotype to PTSD re-experiencing symptom. More... | Non-significant |
| Spagnolo, P. A.,2016 | PTSD avoidance symptoms | F(1, 46)=2.91, P-value=0.09 F(1, 46)=2.91, P-value=0.09 | There was no main effect of genotype to PTSD avoidance sympt...... There was no main effect of genotype to PTSD avoidance symptom. More... | Non-significant |
| Pardini, M.,2012 | PTSD | C/- compared with T/T: In TPBI subjects without vmPFC lesi...... C/- compared with T/T: In TPBI subjects without vmPFC lesions: P-value= 0.40. In the vmPFC lesion group: P-value= 0.51. More... | No significant difference in PTSD prevalence between genotyp...... No significant difference in PTSD prevalence between genotypes in both subjects. More... | Non-significant |
SNP related genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| FAAH | fatty acid amide hydrolase | 1p35-p34 | 8(3/5/0) |
SNPs in LD with rs324420 (count: 10)
Literature-origin SNPs (count: 0)
LD-proxies (count: 10)
SNP related eQTL (count: 1)