PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Pardini, M.,2012 PMID: 22832737
Citation	Pardini, M., et al. (2012). "Fatty-acid amide hydrolase polymorphisms and post-traumatic stress disorder after penetrating brain injury." Transl Psychiatry 2: e75.
Phenotype	PTSD, Reexperiencing symptoms, Avoidance symptoms, Arousal symptoms
Trauma	Combat-related penetrating traumatic brain injury
Study Design	Cross-sectional study
Study Type	Candidate gene association study
Sample Size	115 samples
SNP/Marker Size	7 SNPs
Predominant Ethnicity	Caucasian
Population	Not mentioned
Gender	All males
Age	Not mentioned

Detail Info

Sample Diagnosis	DSM-IV-TR
Related Diagnostic Tools	Early Trauma Inventory (ETI), Structured Clinical Interview for DSM-IV-TR Axis I disorders, Clinician-Administered PTSD Scale(CAPS)
Sample Status	PTBI subjects enrolled in the VHIS registry were included in the study if they agreed to undergo genetic analysis for FAAH polymorphisms and if their medical history was negative for alcohol or substance-abuse disorder, dementia, mood or psychotic disorder as assessed by clinical data.
Controls Exposed	NA
Replication Size	None
Result Summary	We showed that rs2295633, a single-nucleotide polymorphism of FAAH, was significantly associated with PTSD diagnosis in subjects without lesions in the ventromedial prefrontal cortex. Moreover, the presence of the C allele was associated with more severe re-experiencing of traumaand morenegative reported childhood experiences. In conclusion, our data suggest that FAAH has an important role in PTSD through modulation of aversive memories and point to both a novel therapeutic target and a possible risk marker for this condition.
Potential Biomarker	FAAH has an important role in PTSD through modulation of aversive memories and point to both a novel therapeutic target and a possible risk marker for this condition.

Genetic result reported by this study

Normal genetic result reported by this study (count: 10)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs324420	PTSD	FAAH	C/- compared with T/T: In TPBI subjects without vmPFC lesions: P-value= 0.40. In the vmPFC lesion group: P-value= 0.51.	No significant difference in PTSD prevalence between genotyp...... No significant difference in PTSD prevalence between genotypes in both subjects. More...	Non-significant
rs2295633	Avoidance symptoms	FAAH	C/- compared with T/T: In patients with a PTSD clinical diagnosis without vmPFC damage: P-value= 0.63, z=-0.4. In whole sample without vmPFC damage: P-value= 0.4, z=-0.8. In whole sample with vmPFC damage: P-value= 0.6, z=-1.6.	There was no difference in the frequency of cluster 'C' (avo...... There was no difference in the frequency of cluster 'C' (avoidance). Moreover, taking into account the whole sample of patients with vmPFC damage, there were no differences in frequency of cluster 'C' symptoms. More...	Non-significant
rs2295633	Arousal symptoms	FAAH	C/- compared with T/T: In patients with a PTSD clinical diagnosis without vmPFC damage: P-value= 0.58, z=-0.6. In whole sample without vmPFC damage: P-value= 0.85, z=-0.78. In whole sample with vmPFC damage: P-value= 0.5, z=-0.8.	There was no difference in the frequency of cluster 'D' (aro...... There was no difference in the frequency of cluster 'D' (arousal). Moreover, taking into account the whole sample of patients with vmPFC damage, there were no differences in frequency of cluster 'D' symptoms. More...	Non-significant
rs324419	PTSD	FAAH	C/- compared with T/T: In TPBI subjects without vmPFC lesions: P-value= 0.64. In the vmPFC lesion group: P-value= 0.21.	No significant difference in PTSD prevalence between genotyp...... No significant difference in PTSD prevalence between genotypes in both subjects. More...	Non-significant
rs2295633	Reexperiencing symptoms	FAAH	C/- compared with T/T: In patients with a PTSD clinical diagnosis without vmPFC damage: P-value= 0.005, z=-2.73. In whole sample without vmPFC damage: P-value= 0.004, z=-2.86. In whole sample with vmPFC damage: P-value= 0.4, z=-0.9.	C/- subjects showed significantly more PTSD cluster 'B' symp...... C/- subjects showed significantly more PTSD cluster 'B' symptoms according to the DSM-IV-TR diagnostic criteria (persistent re-experiencing of the traumatic event) than T/T subjects both taking into account only those patients with a PTSD clinical diagnosis or the whole experimental group. Moreover, taking into account the whole sample of patients with vmPFC damage, there were no differences in frequency of cluster 'B' symptoms. More...	Significant
rs2295633	PTSD	FAAH	C/- compared with T/T: In TPBI subjects without vmPFC lesions: X²= 10.1; P-value= 0.001. In the vmPFC lesion group: X²= 0.35; P-value= 0.55.	In TPBI subjects without vmPFC lesions, rs2295633 was the on...... In TPBI subjects without vmPFC lesions, rs2295633 was the only FAAH SNP to reveal a significant difference in PTSD prevalence. No FAAH SNPs revealed any significant difference in PTSD prevalence between the C/- compared with T/T groups when analyzing only those subjects with vmPFC lesions. More...	Significant
rs913168	PTSD	FAAH	C/- compared with T/T: In TPBI subjects without vmPFC lesions: P-value= 0.18. In the vmPFC lesion group: P-value= 0.86.	No significant difference in PTSD prevalence between genotyp...... No significant difference in PTSD prevalence between genotypes in both subjects. More...	Non-significant
rs7524148	PTSD	FAAH	No detail information	No significant difference in PTSD prevalence between genotyp...... No significant difference in PTSD prevalence between genotypes in both subjects. More...	Non-significant
rs3766246	PTSD	FAAH	C/- compared with T/T: In TPBI subjects without vmPFC lesions: P-value= 0.6. In the vmPFC lesion group: P-value= 0.09.	No significant difference in PTSD prevalence between genotyp...... No significant difference in PTSD prevalence between genotypes in both subjects. More...	Non-significant
rs6703669	PTSD	FAAH	C/- compared with T/T: In TPBI subjects without vmPFC lesions: P-value= 0.18. In the vmPFC lesion group: P-value= 0.34.	No significant difference in PTSD prevalence between genotyp...... No significant difference in PTSD prevalence between genotypes in both subjects. More...	Non-significant