Study Report
Study Information
Basic Info
| Reference |
Spagnolo, P. A.,2016 PMID: 27716956
|
| Citation |
Spagnolo, P. A., et al. (2016). "FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence." Alcohol Clin Exp Res 40(11): 2426-2434. |
| Phenotype |
PTSD symptom severity, PTSD hyperarousal symptom, PTSD avoidance symptom, PTSD re-experiencing symptom. |
| Trauma |
Various |
| Study Design |
Longitudinal study |
| Study Type |
Candidate gene association study |
| Sample Size |
49 samples |
| SNP/Marker Size |
1 SNP |
| Predominant Ethnicity |
Black, Caucasian |
| Population |
American |
| Gender |
25 males, 24 females |
| Age |
Mean age=40.8 years,SD=8.1 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Alcohol dependence scale (ADS), PTSD Symptom severity index (PSSI), the Addiction Severity Index, the NEO Personality Inventory revised. |
| Sample Status |
All subjects were treatment-seeking alcoholics enrolled in a 4-week inpatient experimentalmedicine study for treating comorbid AD and PTSD at the National Institutes of Health (NIH) Clinical Center in Bethesda. |
| Controls Exposed |
NA |
| Replication Size |
None |
| Result Summary |
FAAH C385A carriers also had decreased subjective anxiety responses to the stress challenge. Similar effects of FAAH C385A genotype were found at the level of clinical PTSD symptom severity, in particular in the arousal domain. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 4)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs324420
|
PTSD avoidance symptoms |
FAAH |
F(1, 46)=2.91, P-value=0.09 |
There was no main effect of genotype to PTSD avoidance sympt......
There was no main effect of genotype to PTSD avoidance symptom.
More...
|
Non-significant |
|
rs324420
|
PTSD re-experiencing symptoms |
FAAH |
F(1, 52)=0.06, P-value=0.80 |
There was no main effect of genotype to PTSD re-experiencing......
There was no main effect of genotype to PTSD re-experiencing symptom.
More...
|
Non-significant |
|
rs324420
|
PTSD hyperarousal symptoms |
FAAH |
F(1, 47)=6.04, P-value=0.02 |
There was a main effect of genotype on hyperarousal, such th......
There was a main effect of genotype on hyperarousal, such that subjects carrying the low-expressing C385A variant exhibited decreased arousal compared to C homozygotes.
More...
|
Significant |
|
rs324420
|
PTSD symptoms |
FAAH |
F(1, 42)=1.18, P-value=0.29 |
There was no main effect of genotype to PTSD total symptom.
There was no main effect of genotype to PTSD total symptom.
|
Non-significant |
