PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Spagnolo, P. A., et al. (2016). "FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence." Alcohol Clin Exp Res 40(11): 2426-2434.
Phenotype PTSD symptom severity, PTSD hyperarousal symptom, PTSD avoidance symptom, PTSD re-experiencing symptom.
Trauma Various
Study Design Longitudinal study
Study Type Candidate gene association study
Sample Size 49 samples
SNP/Marker Size 1 SNP
Predominant Ethnicity Black, Caucasian
Population American
Gender 25 males, 24 females
Age Mean age=40.8 years,SD=8.1

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 4)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
rs324420 PTSD avoidance symptoms FAAH F(1, 46)=2.91, P-value=0.09 There was no main effect of genotype to PTSD avoidance sympt...... There was no main effect of genotype to PTSD avoidance symptom. More... Non-significant
rs324420 PTSD re-experiencing symptoms FAAH F(1, 52)=0.06, P-value=0.80 There was no main effect of genotype to PTSD re-experiencing...... There was no main effect of genotype to PTSD re-experiencing symptom. More... Non-significant
rs324420 PTSD hyperarousal symptoms FAAH F(1, 47)=6.04, P-value=0.02 There was a main effect of genotype on hyperarousal, such th...... There was a main effect of genotype on hyperarousal, such that subjects carrying the low-expressing C385A variant exhibited decreased arousal compared to C homozygotes. More... Significant
rs324420 PTSD symptoms FAAH F(1, 42)=1.18, P-value=0.29 There was no main effect of genotype to PTSD total symptom. There was no main effect of genotype to PTSD total symptom. Non-significant